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Department of Biological and Medical Sciences
Faculty of Health and Life Sciences
+44 (0)1865 484146
Tonge Building laboratories
U14572 Clinical Biochemistry and Pharmacology (Double Honours Module)
U14592 Molecular Medicine (Honours module)
MSc Module P1112 Molecular Basis of Human Genetic Diseases
I have surpervised more than 20 PhD student, whose work has focused on insect or human Cys loop ligand gated ion channels.
I am currently supervising two PhD students as a Director of studies and three others as a second supervisor.
The Molecular Neuroscience research group in the Department of Biological and Medical Sciences has a long-term interest in the structural and functional relationships of ligand-gated ion channels, with particular emphasis on human nicotinic acetylcholine receptors (nAChR) expressed in the central nervous system. These receptors have been implicated in a wide range of diseases of the brain, including Alzheimer’s and Parkinson’s diseases, Tourette syndrome, schizophremia, autism, drug addiction and attention deficit disorders, and are therefore high-quality targets for drug therapy.
The overall goal of the research is to map and identify functional sites in the receptors that help us to understand better the how these important molecules generates signals in the brain. These sites can provide new strategies to develop more specific and safer therapeutic drugs.
The techniques of molecular biology, in vitro functional studies using primary or clonal cell cultures, radioligand-binding assays and electrophysiological recordings from the ligand-gated ion channels are combined to provide a multidisciplinary approach to the topic.
Brookes University Research Excellence Award
Nigel Groome PhD sudentship awards
Current Projects include:
A) Characterisation of plant- and animal-derived compounds for probing the structure and function of nAChRs to provide new leads for the development of selective therapeutic substances.
B) Mapping and identification of allosteric pathways in nicotinic receptors.
C) Effects of RIC-3 polymorphisms on the expression of nicotinic acetylcholine receptors
Pharmacology of ligand-gated ion channels
Electrophysiological recordings from ligand gated ion channels expressed heterologously in Xenopus oocytes.
The substituted cysteine scanning method applied to ion channels expressed in Xenopus oocytes
Mutagenesis and concatenation of ligand gated ion channels
2013 Neurotalk-2013, Xian, China
2014 3RD Welcome Trust Conference on Nicotinic Receptor Research, Cambridge, UK
2015 Membrane Signalling and Transport: Computation and Experiment, April, Oxford
2015 IST 18thWorld Congress 2015, September, Oxford
2016 Annual Meeting of the Chilena Pharmacological Society, December, Chiloe, Chile
2017 Workshop Instituto Butantan – United Kingdom, Science Dissemination, Animal Biology and Neuroscience, March, Sao Paulo, Brazil
2017 Nicotinic receptor research Conference, May, Crete,Greece
Meeting of the Chilean Pharmacological Society, Chiloe, Chile, December 2016
Workshop Instituto Butantan – United Kingdom Science Dissemination, Animal Biology and Neuroscience, sao paulo, Brazil, March 2017