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Department of Biological and Medical Sciences
Faculty of Health and Life Sciences
Sinclair Annex G.01 - Bioimaging Office
I manage the Oxford Brookes Centre for Bioimaging. My main duty is to train and help people to perform electron microscopy, and to make sure all microscopes and equipment are well maintained and running smoothly.
My background is in Cell Biology, and I spent most of my scientific career doing light and electron microscopy, biochemistry, and molecular biology of cancer cells and protozoan parasites (see references). In 1999, I came to the UK to do my PhD at the University of Manchester. After a very successfull PhD, I carried on as a postdoctoral researcher, first in Manchester and then at the University of Oxford. More recently (in 2019), I ‘climbed uphill’ to Oxford Brookes, where I worked as a Module Leader in Cell Biology before becoming the Bioimaging Manager.
I have more than 20 years of experience in electron and light microscopy, and a real passion for looking at very small things down the microscope! I believe in pushing microscopes to their limit, and I love training and helping researchers to make their microscopic dreams come true. The best part of my job is seeing users become independent and confident to generate data that is both meaningful and beautiful.
Module Leader - Context of the Cell module - Oxford Brookes University - 2019
Tutor in Molecular Parasitology - University of Oxford (2017-2018)
Context of the Cell
Dean S, Moreira-Leite F, Gull K (2019). Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function. eLife 8: e42282. 10.7554/eLife.42282
Sunter JD, Yanase R, Wang Z, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Gull K (2019). Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host. PNAS 116:6351-6360. 10.1073/pnas.1812462116.
Sunter JD, Moreira-Leite F, Gull K. (2018). Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in Leishmania. Open Biol 8:180124. 10.1098/rsob.180124.
Edwards BFL, Wheeler RJ, Barker AR, Moreira-Leite FF, Gull K, Sunter JD (2018). Direction of flagellum beat propagation is controlled by proximal/distal outer dynein arm asymmetry. PNAS 115:E7341-E7350. 10.1073/pnas.1805827115
Varga V, Moreira-Leite F, Portman N, Gull K (2017). Protein diversity in discrete structures at the distal tip of the trypanosome flagellum. PNAS 114:E6546-E6555. 10.1073/pnas.1703553114
Dean S, Moreira-Leite F, Varga V, Gull K (2016). Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes. PNAS 113(35):E5135-43. 10.1073/pnas.1604258113
Lacomble S, Vaughan S, Deghelt M, Moreira-Leite FF, Gull K (2012). A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains. Protist 163:602-15. 10.1016/j.protis.2011.10.010
Moreira-Leite FF, Harrison LR, Mironov A, Roberts RA, Dive C (2010). Inducible EGFR T790M-mediated gefitinib resistance in non-small cell lung cancer cells does not modulate sensitivity to PI103 provoked autophagy. J Thorac Oncol 5:765-77. 10.1097/JTO.0b013e3181d95d93
Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, Miller C, Saunders EK, White DJ, Will AM, Eden T, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H (2007). Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosomes Cancer 46:359-72. 10.1002/gcc.20417
Briggs LJ, McKean PG, Baines A, Moreira-Leite F, Davidge J, Vaughan S, Gull K (2004). The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J Cell Sci 117:1641-51. 10.1242/jcs.00995
Moreira-Leite FF, Sherwin T, Kohl L, Gull K (2001). A trypanosome structure involved in transmitting cytoplasmic information during cell division. Science 294:610-2. PMID: 11641501
Bastin P, Pullen TJ, Moreira-Leite FF, Gull K (2000). Inside and outside of the trypanosome flagellum: a multifunctional organelle. Microbes Infect 2:1865-74. PMID: 11165931
Moreira-Leite FF, de Souza W, da Cunha-e-Silva NL (1999). Purification of the paraflagellar rod of the trypanosomatid Herpetomonas megaseliae and identification of some of its minor components. Mol Biochem Parasitol 104:131-40. PMID: 10589987