Department of Biological and Medical Sciences

Publications

  • Peer reviewed – Journals

    1. Zarkan, A., Macklyne, H.-R., Chirgadze, D.Y., Bond, A.D., Hesketh, A.R., and Hong, H.-J. (2017) Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci. Rep. Accepted.

    2. Lee, D.-R., Cheng, J., Lee, S.-K., Hong, H.-J., Song, J., Yang, S.H., and Suh, J.-W. (2016) Anti-multi drug resistant pathogen activity of siderochelin A, produced by a novel Amycolatopsis sp. KCTC 29142. Korean J. Microbiol. 52:327-345.

    3. Hong, H.-J. (2016) Construction of a bioassay system to identify extracellular agents targeting bacterial cell envelope. Methods Mol Biol. 1440:125-137.

    4. Hesketh, A., and Hong, H.-J. (2016) Microarray analysis to monitor bacterial cell wall homeostasis. Methods Mol Biol. 1440:31-46.

    5. Zarkan, A., Macklyne, H.-R., Truman, A.W., Hesketh, A.R., and Hong, H.-J. (2016) The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to zinc(II). Sci. Rep. 6:19602.

    6. Cha, J.-Y., Han, S., Hong, H.-J., Cho, H., Kim, D., Kwon, Y., Kwon, S.-K., Crüsemann, M., Lee, Y.B., Kim, J.F., Giaever, G., Nislow, C., Moore, B.S., Thomashow, L.S., Weller, D.M., and Kwak, Y.-S. (2016) Microbial and biochemical basis of a Fusarium wilt suppressive soil. ISME J. 10:119-129.

    7. Novotna, G.B., Kwun, M.J., and Hong, H.-J. (2015) In vivo characterization of the activation and interaction of the VanR/VanS two-component regulatory system controlling glycopeptide antibiotic resistance in two related Streptomyces species. Antimicrob. Agents Chemother. 60:1627-1637.

    8. Hesketh, A., Deery, M., Hong, H.-J. (2015) High-resolution mass spectrometry based proteomic analysis of the response to vancomycin-induced cell wall stress in Streptomyces coelicolor A3(2). J Proteome Res.14:2915-2928

    9. Kwun, M.J., Cheng, J., Yang, S.H., Lee, D.R., Shu, J.-W., and Hong, H.-J. (2014) Draft genome sequence of ristocetin-producing strain Amycolatopsis sp. Strain MJM2582 isolated in South Korea. Genome Announc. 2:e01091-14.

    10. Kwun, M.J., and Hong, H.-J. (2014) Draft genome sequence of Amycolatopsis lurida NRRL 2430, producer of the glycopeptide family antibiotic ristocetin. Genome Announc. 2:e01050-14.

    11. Kwun, M.J., and Hong, H.-J. (2014) The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system. Antimicrob. Agents Chemother. 58:6303-6310.

    12. Kwun, M.J., and Hong, H.-J. (2014) Genome sequence of Streptomyces toyocaensis NRRL 15009, producer of the glycopeptide antibiotic A47934. Genome Announc. 2:e00749-14.

    13. Truman, A.W., Kwun, M.J., Cheng, J., Yang, S.H., Shu, J.-W., and Hong, H.-J. (2014) Antibiotic resistance mechanisms inform discovery: Identification and characterization of a novel Amycolatopsis strain producing Ristocetin. Antimicrob. Agents Chemother. 58:5687-5695.

    14. Hesketh, A.R., and Hong, H.-J. (2013) Comparative and functional genomics as tools for understanding vancomycin resistance in bacteria. Nova Science Publishers, New York.

    15. Kwun, M.J., Novotna, G., Hesketh, A.R., Hill, L., and Hong, H.-J. (2013) Induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. Antimicrob. Agents Chemother. 57:4470-4480.

    16. Duong, A., Capstick, D.S., Berardo, C.D., Findlay, K., Hesketh, A., Hong, H.-J., and Elliot, M.A. (2012) Aerial development in Streptomyces coelicolor requires sortase activity. Mol Microbiol. 83:992-1005.

    17. Novotna, G., Vincent, K., Hill, C., Liu, C., and Hong, H.-J. (2012) A novel membrane protein, VanJ, conferring resistance to teicoplanin. Antimicrob. Agents Chemother. 56:1784-1796.

    18. Hesketh, A., Hill, C., Mokhtar, J, Novotna, G., Tran, N., Bibb, M., and Hong, H.-J. (2011) Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope. BMC Genomics. 12:226.

    19. Hong, H.-J. (2010) Studying gene induction of glycopeptide resistance using gene swapping. Methods Mol Biol. 642:45-62.

    20. Koteva, K., Hong, H.-J., Wang, X.D., Nazi, I., Hughes, D., Naldrett, M.J., Butter, M.J., and Wright, G.D. (2010) A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. Nat Chem Biol. 6:327-329.

    21. Kallifidas, D., Pascoe, B., Owen, G.A., Strain-Damerell, C.M., Hong, H.-J., and Paget, M.S. (2010) The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor. J Bacteriol. 192:608-611.

    22. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2008) Vancomycin resistance VanRS two-component systems. Adv Exp Med Biol, 631:200-213.

    23. Hutchings, M.I., Hong, H.-J., Leibovitz, E., Sutcliffe, I.C., and Buttner, M.J. (2006) The SigE cell envelope stress signal of Streptomyces coelicolor is influenced by a novel lipoprotein, CseA. J Bacteriol. 188(20):7222-7229.

    24. Hutchings, M.I., Hong, H.-J., and Buttner M.J. (2006) The vancomycin resistance VanRS signal transduction system of Streptomyces coelicolor. Mol. Microbiol. 59(3):923-935.

    25. Hong, H.-J., Hutchings, M.I., Hill, L., and Buttner, M.J. (2005) The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. J. Biol. Chem. 280(13):13055-13061.

    26. Hong, H.-J., Hutchings, M.I., Neu, J.M., Wright G.D., and Buttner, M.J. (2004) Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. Mol. Microbiol. 52(4):1107-1121.

    27. Hong, H.-J., Paget, M.S.B., and Buttner, M.J. (2002) A signal transduction system in Streptomyces coelicolor that activated expression of a putative cell wall glycan operon in response to vancomycin and other cell wall-specific antibiotics. Mol. Microbiol. 44(5):1199-1211.

    28. Hong, H.-J., Paget, M.S.B., Hutchings, M.I., Leibovitz, E., and Buttner, M.J. (2002) Sensing and responding to cell envelope stress in Streptomyces coelicolor. Actinomycetol. 16(2):41-47.

    29. Bibb, M.J., Blomfield, I.C., Browning, D., Buck, M., Busby, S., Buttner, M.J., Dixon, R., Dorman, C.J., Finn, R.D., Gerdes, K., Green, J., Harris, A.K.P., van Heel, M., Henkin, T.M., Hoch, J.A., Hong, H.-J., Hood, D., Lee, D., Møller-Jensen, J., Morrison, D.A., Moxon, R., Müller-Hill, B., Neidhardt, F.C., Orlova, E.V., Paget, M.S.B., Salmond, G.P.C., Schleif, R., Whitehead, N.A., and Williams, P. (2002) Signal, switches, regulons and cascades: control of bacterial gene expression. Hodgson, D.A., and Thomas, C.M. (eds). Cambridge University Press.

    30. Kim, E.-S., Hong, H.-J., Choi, C.-Y., and Cohen, S.N. (2001) Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription. J Bacteriol. 183(7):2198-2203.

    31. Hong, H.-J., Lee J.-E., Ahn, J.-E., and Kim, D.-I. (1998) Enhanced Production of Digoxin by Digitoxin Biotransformation Using In Situ Adsorption in Digitalis lanata Cell Culture. J. Microbiol. Biotechnol. 8(5):478-483.

    32. Park, Y.-S., Kim, H.-K., Hong, H.-J., and Kim, D.-I. (1995) Biotransformation using immobilized cell culture of Digitalis lanata. J. of Korean Ind. & Eng. Chemistry 6(2):222-229.

    33. Kim, H.-K., Hong, H.-J., and Kim, D.-I. (1994) Fermentation, cell culture, bioprocessing: Digoxin production by using biotransformation in Digitalis lanata cell suspension cultures. Korean Journal of Applied Microbiology and Biotechnology 22(6):651-658.

    Peer reviewed - Conference proceedings

    1. Hong, H.-J. (2015) Antibiotics for the future: Reistance informs discovery. 2015 International Meeting of the Microbiological Society of Korea, Changwon, South Korea, p 49.

    2. Kwun M.J., Novotna, G., Hesketh, A.R., Hill, L., and Hong, H.-J. (2013) Characterisation of the effector ligand recognised by VanS, a key protein triggering resistance to vancomycin. 16th International Symposium on the Genetics of Industrial Microorganisms, Cancun, Mexico, p 43.

    3. Hong, H.-J. (2013) Genome-wide dynamics for bacterial cell response to antibiotics, 1st China-Europe Symposium “The Biology of Actinomycete Antibiotic Production”, Beijing, China, p 31.

    4. Kwun M.J., Novotna, G., Hesketh, A.R., Hill, L., and Hong, H.-J. (2013) Induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. Society for General Microbiology, Manchester, UK, p 68.

    5. Al Zarkan, M.A., Heather M., and Hong, H.-J. (2013) Vancomycin incudes the zinc starvation response in S. coelicolor. Society for General Microbiology, Manchester, UK, p 68.

    6. Liu, W., and Hong, H.-J. (2013) Characterisation of a novel membrane protein VanJ conferring resistance to teicoplanin. Society for General Microbiology, Manchester, UK, p 112.

    7. Novotna, G., Hill, C., Vincent, K., Liu, C., and Hong, H.-J. (2011) A novel membrane protein, VanJ, conferring resistance to teicoplanin. 16th International Symposium on the Biology of Actinomycetes, Vuerto Vallarta, Mexico, p 97.

    8. Novotna, G., Hill, C., Vicent, K., Liu, C., and Hong, H.-J. (2011) A novel membrane protein, VanJ, conferring resistance to teicoplanin. 2nd Great Wall Symposium - The Dynamics of Peptidoglycan Structure and Function : New Insights into The ‘Great Wall’. Cascais, Portugal, p 73.

    9. Novotna, G., Hill, C., Vincent, K., and Hong, H.-J. (2011) Glycopeptide resistance: Old and New. 2nd International Symposium of the Collaborative Research Centre 766 - The Bacterial Envelope: Structure, Function, and Infection Interface, Function, and Infection Interface at Kloster Irsee conference centre. Kaufbeuren, Germany, p 83.

    10. Novotna, G., and Hong, H.-J. (2010) VanJ – A novel resistance to glycopeptides. UKCan-BaCWAN Meeting,White Oaks Conference Resort & Spa, Niagara-on-the-lake, Ontario, Canada, p 27.

    11. Novotna, G., Ulanova, D., and Hong, H.-J. (2009) Glycopeptide resistance VanS/VanR two-component wystems, UK-BaCWAN Meeting, Woodland Grange conference centre, Leamington Spa, Warwichkshire, UK, p 36.

    12. Hong, H.-J. (2009) Streptomyces coelicolor as a model system for characterising resistance to antibiotics that target the bacterial cell wall. Society for General Microbiology, Edinburgh Conference Centre, Herriot-Watt University, UK, p 31.

    13. Novotna, G., Ulanova, D., and Hong, H.-J. (2009) What induces resistance to glycopeptide antibiotics? 15th International Symposium on the Biology of Actinomycetes, Shanghai, China, p 17.

    14. Novotna, G., Mitchell, H., and Hong, H.-J. (2009) Glycopeptide resistance VanS/VanR two-component wystems. 15th International Symposium on the Biology of Actinomycetes, Shanghai, China, p 103.

    15. Hong, H.-J. (2009) Bacterial cell wall homeostasis. Seoul International Conference on Actinomycetes, Seoul National University, Seoul, South Korea, p 5.

    16. Hong, H.-J. (2008) Streptomyces coelicolor as a model system for characterising resistance to antibiotics that target the bacterial cell wall. Japan-UK Workshop on Genomics of Antibiotic producing Actinomycetes: Implications and Applications. Nihon University, Tokyo, Japan, p 28.

    17. Hong, H.-J., Hutchings, M., and Buttner, M.J. (2007) Inducible vancomycin resistance in bacteria. UK-BaCWAN Meeting, Honiley court Hotel & Conference centre, West midlands, UK.

    18. Hong, H.-J. (2006) Characterization of bacterial responses to cell wall-specific antibiotic attack. Korean Streptomyces meeting. Han-Hwa Resort, Yong-In, South Korea.

    19. Hong, H.-J. (2006) Outsmarting the vancomycin resistance system. UK-BaCWAN Meeting, Warwick Biological Sciences, University of Warwick, UK.

    20. Hong, H.-J. (2006) Sneaking past the VanS vanguard: Outsmarting the vancomycin resistance system. UK Streptomyces Community Dissemination Meeting, John Innes Centre, Norwich, UK.

    21. Hong, H.-J., and Buttner, M.J. (2005) The role of novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. International Union of Microbiological Societies meeting, San Francisco, USA, p 106.

    22. Hong, H.-J., and Buttner, M.J. (2005) Novel vancomycin resistance system in Streptomyces coelicolor. International meeting of the microbiological society of Korea, Hundai Sungwoo Resort, Gangwondo, South Korea, p 143-147.

    23. Hong, H.-J., Hutchings, M.I., Hill, L., and Buttner, M.J. (2005) The role of novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. 5th International symposium on antimicrobial agents and resistance, COEX Center, Seoul, South Korea.

    24. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2005) The function of novel gene vanK for vancomycin resistance system in Streptomyces coelicolor. Microbes in Norwich, UK.

    25. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2005) The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. UK Streptomyces Community Dissemination Meeting, University of Surrey, Guildford, UK, p 45.

    26. Hong, H.-J. (2004) Superbug threat!: Are we living in the “Era of Phamageddon?”. 29th Annual Meeting of Korean Scientists and Engineers’ Association in the UK for 30th anniversary of KSEAUK, University of College London, UK.

    27. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2003) Inducible cell wall remodelling conferring vancomycin resistance in Streptomcyes coelicolor. 13th International Symposium on the Biology of Actinomycetes, Melbourne, Australia, p 26.

    28. Hong, H.-J., and Buttner, M.J. (2003) Pharmageddon: the spread of inducible vancomycin resistance in bacteria. Norwich Research Park Symposium “Drugs and Bugs”, Institute of Food Research Lecture Theatre, Norwich, UK.

    29. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2003) The Vancomycin resistance system in Strpetomyces coelicolor: identification of two novel genes. UK Streptomyces Community Dissemination Meeting, University of Surrey, Guildford, UK.

    30. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2003) Novel vancomycin resistance gene cluster in Streptomyces coelicolor. Microbes in Morwich, UK.

    31. Hong, H.-J. (2002) Induction of vancomycin resistance in bacteria – how cell walls talk to the chromosome. Norwich Research Park Symposium “Signalling and Communication”, Institute of Food Research Lecture Theatre, Norwich, UK.

    32. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2002) Novel vancomycin-resistance gene cluster in Streptomyces coelicolor. JIC Annual Science Meeting, Norwich, UK.

    33. Hong, H.-J., Hutchings, M.I., and Buttner, M.J. (2002) Novel vancomycin resistance gene cluster in Streptomyces coelicolor. 9th International Symposium on the Genetic on Industrial Microorganisms, Gyeonju, South Korea, p 90.

    34. Paget, M.S.B., Hong, H.-J., Bibb, M.J., and Buttner, M.J. (2002) The ECF sigma factors of Streptomcyes coelicolor A(3)2. 150th Society for General Microbiology, University of Warwick, UK.

    35. Hong, H.-J., and Buttner, M.J. (2002) Characterisation of a vancomycin resistance system in Streptomyces coelicolor. Microbes in Norwich, UK.

    36. Hong, H.-J., and Buttner, M.J. (2001) Characterisation of a vancomycin resistance system in Streptomyces coelicolor. JIC Annual Science Meeting, Norwich, UK.

    37. Hong, H.-J., Paget, M.S.B., Leibovitz, E., and Buttner, M.J. (2001) Sensing and responding to cell envelope stress in Streptomyces coelicolor, 12th International Symposium on the Biology of Actinomycetes, Vancouver, Canada, p 122. 38. Hong, H.-J., Paget, M.S.B., and Buttner, M.J. (2001) Sensing and responding to cell envelope stress in Streptomyces. 13th RNA Polymerase Workshop Nottingham, UK.

    39. Hong, H.-J. (2000) Sensing and responding to cell envelope stress in Streptomyces coelicolor. The 26th Annual Meeting of Korean Scientists and Engineers’ association in the UK, Oxford, UK, p 16.

    40. Hong, H.-J., and Buttner, M.J. (2000) A signal transduction system in Streptomyces coelicolor that activates cell wall glycan biosynthesis in response to vancomycin and other cell wall-specific antibiotics. JIC Annual Science Meeting, Norwich, UK.

    41. Kim, D.I., Hong, H.-J., Lee, J.E., and Choi, Y.S. (1997) Extractive bioconversion using solid adsorbent in plant cell suspension cultures. 4th Asia-Pacific Biochemical Engineering Conference, Central Garden Hotel, Beijing, China.

    42. Hong, H.-J., Lee, J.E., Choi, Y.S., and Kim, D.I. (1997) Integrated bioprocessing for enhanced production of digoxin in Digitalis lanata suspension cell cultures. 2nd Inha-Wuxi Biotechnology Symposium, Inha University, South Korea.

    43. Kim, D.I., Hong, H.-J., and Lee. J.E. (1995) Enhanced bioconversion of digitoxin to digoxin using in situ adsorption in plant cell cultures. International Chemical Congress of Pacific Basin Societies (Pacifichem'95), Hilton Hotel, Honolulu, Hawaii, USA.

    44. Hwang, Y.S., Hong, H.-J., and Kim, D.I. (1995) Process development for de novo biosynthesis and biotransformation using plant cell cultures. International Symposium on Functional Biomaterials, Seoul National University Cultural Center, Seoul, South Korea.

    45. Kim, H.K., Park, Y.S., Hong, H.-J., and Kim, D.I. (1995) Process strategy for biotransformation of digitoxin to digoxin by plant cell cultures. 7th European Congress on Biotechnology, Nice, France.

    Patents

    1. Hong, H.-J., Hutchings, M.I., Buttner, M.J. (WO 2005001118). Detection system: a patent application covering the use of femX mutant bioassay as the basis of a broad-range, generic screening for cell envelope-specific antibiotics was filed through Plant Bioscience Ltd.

    2. Hong, H.-J., Paget, M.S.B., Buttner, M.J. (US 2004014066) Screening system: a patent application covering the use of a vanJ promoter-reporter gene bioassay as the basis of a broad-range, generic screening for cell envelope-specific antibiotics was filed through Plant Bioscience Ltd.

    3. Hong, H.-J., Paget, M.S.B., Buttner, M.J. (WO 03012128) Detection system: a patent application covering the use of a sigE promoter-reporter gene bioassay as the basis of a broad-range, generic screening for cell envelope-specific antibiotics was filed through Plant Bioscience Ltd.