Department of Biological and Medical Sciences

Publications and Reviews

  • Laura’s publications

    Click here to see a full list of Laura's publications

    Armstrong, Matthew J; Hull, Diana; Guo, Kathy; Barton, Darren; Hazlehurst, Jonathan M; Gathercole, Laura L; Nasiri, Maryam; Yu, Jinglei; Gough, Stephen C; Newsome, Philip N. 2016. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. Journal of hepatology. 64 (2), 399-408. Elsevier.

    Gathercole, Laura L; Hazlehurst, Jonathan M; Armstrong, Matthew J; Crowley, Rachel; Boocock, Sarah; O'Reilly, Michael W; Round, Maria; Brown, Rachel; Bolton, Shaun; Cramb, Robert. 2016. Advanced non‐alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver International. 36 (11), 1704-1712.

    Larner, Dean P; Morgan, Stuart A; Gathercole, Laura L; Doig, Craig L; Guest, Phil; Weston, Christopher; Hazeldine, Jon; Tomlinson, Jeremy W; Stewart, Paul M; Lavery, Gareth G. 2016. Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease. Endocrinology. 157 (9), 3493-3504. Endocrine Society Washington, DC.

    Woods, CP; Corrigan, M; Gathercole, L; Taylor, A; Hughes, B; Gaoatswe, G; Manolopoulos, K; Hogan, AE; O'connell, J; Stewart, PM. 2015. Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT). The Journal of Clinical Endocrinology & Metabolism. 100 (4), 1434-1444. Endocrine Society Chevy Chase, MD.

    Nasiri, Maryam; Nikolaou, Nikolaos; Parajes, Silvia; Krone, Nils P; Valsamakis, George; Mastorakos, George; Hughes, Beverly; Taylor, Angela; Bujalska, Iwona J; Gathercole, Laura L. 2015. 5α-Reductase type 2 regulates glucocorticoid action and metabolic phenotype in human hepatocytes. Endocrinology. 156 (8), 2863-2871. Endocrine Society Chevy Chase, MD.

    Morgan, Stuart A; McCabe, Emma L; Gathercole, Laura L; Hassan-Smith, Zaki K; Larner, Dean P; Bujalska, Iwona J; Stewart, Paul M; Tomlinson, Jeremy W; Lavery, Gareth G. 2014. 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proceedings of the National Academy of Sciences. 111 (24), E2482-E2491. National Acad Sciences.

    Hazlehurst, Jonathan M; Gathercole, Laura L; Nasiri, Maryam; Armstrong, Matthew J; Borrows, Sarah; Yu, Jinglei; Wagenmakers, Anton JM; Stewart, Paul M; Tomlinson, Jeremy W. 2013. Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo. The Journal of Clinical Endocrinology & Metabolism. 98 (4), 1631-1640. Endocrine Society Chevy Chase, MD.

    Morgan, Stuart A; Gathercole, Laura L; Simonet, Claire; Hassan-Smith, Zaki K; Bujalska, Iwona; Guest, Phil; Abrahams, Lianne; Smith, Dave M; Stewart, Paul M; Lavery, Gareth G. 2013. Regulation of lipid metabolism by glucocorticoids and 11β-HSD1 in skeletal muscle. Endocrinology. 154 (7), 2374-2384. Endocrine Society Chevy Chase, MD.

    McNelis, Joanne C; Manolopoulos, Konstantinos N; Gathercole, Laura L; Bujalska, Iwona J; Stewart, Paul M; Tomlinson, Jeremy W; Arlt, Wiebke. 2013. Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake. American Journal of Physiology-Endocrinology and Metabolism. 305 (9), E1134-E1144. Am Physiological Soc.

    Lavery, Gareth G; Zielinska, Agnieszka E; Gathercole, Laura L; Hughes, Beverly; Semjonous, Nina; Guest, Phillip; Saqib, Khalid; Sherlock, Mark; Reynolds, Gary; Morgan, Stuart A. 2012. Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology. 153 (7), 3236-3248. Endocrine Society Chevy Chase, MD.

    McGee, Kirsty C; Shahmanesh, Mohsen; Boothby, Meg; Nightingale, Peter; Gathercole, Laura L; Tripathi, Gyanendra; Harte, Alison L; Shojaee-Moradie, Fariba; Umpleby, A Margot; Das, Satyajit. 2012. Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones. Antiviral therapy. 17 (3), 495.

    Gathercole, Laura L; Morgan, Stuart A; Bujalska, Iwona J; Hauton, David; Stewart, Paul M; Tomlinson, Jeremy W. 2011. Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue. PloS one. 6 (10), e26223. Public Library of Science.

    Gathercole, LL; Morgan, SA; Bujalska, IJ; Stewart, PM; Tomlinson, JW. 2011. Short-and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue. Nutrition & diabetes. 1 (1), e3. Nature Publishing Group.

    Tomlinson, Jeremy W; Durrani, Omar M; Bujalska, Iwona J; Gathercole, Laura L; Tomlins, Paul J; Reuser, Tristan TQ; Rose, Geoffrey E; Curnow, S John; Stewart, Paul M; Walker, Elizabeth A. 2010. The Role of 11ß-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy. The Journal of Clinical Endocrinology & Metabolism. 95 (1), 398-406. Endocrine Society.

    Morgan, Stuart A; Sherlock, Mark; Gathercole, Laura L; Lavery, Gareth G; Lenaghan, Carol; Bujalska, Iwona J; Laber, David; Yu, Alice; Convey, Gemma; Mayers, Rachel. 2009. 11β-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. Diabetes. 58 (11), 2506-2515. Am Diabetes Assoc.

    Boothby, Meg; McGee, Kirsty C; Tomlinson, Jeremy W; Gathercole, Laura L; McTernan, Philip G; Shojaee-Moradie, Fariba; Umpleby, A Margot; Nightingale, Peter; Shahmanesh, Mohsen. 2009. Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 14 (8), 1089-100.

    Bujalska, IJ; Gathercole, LL; Tomlinson, JW; Darimont, C; Ermolieff, J; Fanjul, AN; Rejto, PA; Stewart, PM. 2008. A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. Journal of Endocrinology. 197 (2), 297-307. Soc Endocrinology.

    Gathercole, Laura L; Bujalska, Iwona J; Stewart, Paul M; Tomlinson, Jeremy W. 2007. Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue. The Journal of Clinical Endocrinology & Metabolism. 92 (11), 4332-4339. Endocrine Society.

    Fife, Mark S; Gathercole, Laura; Ogilvie, Emma M; Stock, Carmel JW; Mack, Lisa F; Donn, Rachelle P; Thomson, Wendy; Woo, Patricia. 2007. No evidence for genetic association of interferon regulatory factor 1 in juvenile idiopathic arthritis. Arthritis & Rheumatism. 56 (3), 972-976. Wiley Online Library.

    Reviews

    Gathercole, Laura L; Lavery, Gareth G; Morgan, Stuart A; Cooper, Mark S; Sinclair, Alexandra J; Tomlinson, Jeremy W; Stewart, Paul M. 2013. 11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects. Endocrine reviews. 34 (4), 525-555. Endocrine Society Chevy Chase, MD.

    Gathercole, Laura L; Morgan, Stuart A; Tomlinson, Jeremy W. 2013. Hormonal regulation of lipogenesis. Vitam Horm. 91.

    Gathercole, Laura L; Stewart, Paul M. 2010. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes. The Journal of steroid biochemistry and molecular biology. 122 (1), 21-27. Pergamon.