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Our work explores functional interactions between the brain, lungs and the heart with particular focus on neurophysiological mechanisms underpinning the perception of breathlessness (dyspnoea). We study healthy individuals in whom we can experimentally induce various forms of breathlessness, and clinical populations in collaboration with clinical colleagues in Cardiology, Respiratory Medicine and Clinical Neuroscience at the Oxford University Hospitals.
The research is multidisciplinary involving cardiorespiratory physiology, psychology, cardiology and neurology. Projects are wide ranging including a clinical trial of inhaled furosemide for symptom relief in advanced heart failure and investigation of neurologicalpatients with ischaemic strokes, low grade gliomas or with implanted electrodes for deep brain stimulation involving areas of the brain suspected of being essential for appropriate breathlessness perception.