Department of Biological and Medical Sciences

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  • The ability to regulate gene expression in specific cells and their progeny over time is essential during animal development to generate the diverse array of tissues and organs found in mature organisms. Gene expression must also be strictly regulated during adult life to cope with environmental changes (e.g. infection, available nutrients) and to maintain tissues through careful regulation of stem cells. In humans, failure of correct transcriptional regulation during foetal development usually results in death or severe congenital defects, and in adult life leads to diseases including cancer.