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Maintenance of correct chromosome numbers is absolutely critical for all living organisms. An evolutionarily conserved and self-monitoring surveillance system, the spindle assembly for the mitotic checkpoint (SAC) has therefore emerged to ensure the timely and high fidelity transmission of the genetic material to an offspring. In humans, failure of the SAC is a major determinant of age-related genetic disorders, of aberrant chromosome segregation and genome instability and represents the leading cause of pregnancy loss, birth and development defects. Learn more...