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-Definition of the SAC interactoma
The Spindle Assembly Checkpoint (SAC) is orchestrated by a complex network of interactions that are organised in time and space. The project aims to define the flow of information in the SAC in a narrow spatio-temporal framework.
-Mechanistic understanding of SAC phosphoregulation
Key to the multiple activities of SAC protein components is their regulation by concerted phosphorylation/dephosphorylation cascades. We aim to understand how the catalytic activities of SAC kinases Bub1 and Mps1 control the assembly and disassembly of SAC macromolecular complexes to ensure the proper segregation of the genetic material upon cell division.
-The SAC-KMN-MT axis: new therapeutic opportunities
Central components of the SAC interactome are emerging as potential new targets for the treatment of cancer, birth and development defects. Our efforts are focused on early drug discovery campaigns, ranging from target identification and validation to in vitro preclinical validation studies.
A new area of interest in our group is the structure-based design of novel antigens in an attempt to develop more effective vaccines and the combinatorial assessment of adjuvants to enhance the potency of the vaccines.