Department of Biological and Medical Sciences

Publications

  • Papers

    • Harris, S.E., De Blasio, M.J., Davis, M.A., Kelly, A., Davenport, H.M., Wooding, F.B.P., Blache, D., Meredith, D., Anderson, M., Fowden, A.L., Limesand, S.W. and Forhead, A.J. (2017). Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation. Journal of Physiology ISSN: 0022-3751 eISSN: 0022-3751
    • Foley, D.W., Bermudez, I., Bailey, P.D. and Meredith, D. (2016). A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1. MedChemComm 2016 (7) pp.999-1002
    • Beale, J.H., Parker, J.L., Samsudin, F., Barrett, A.L., Senan, A., Bird, L.E., Scott, D., Owens, R.J., Sansom, M.S., Tucker, S.J., Meredith, D., Fowler, P.W. and Newstead. S. (2015). Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. Structure 23 (10) pp.1889-1899
    • Taylor-Wells, J. and Meredith, D. (2014). The signature sequence region of the human drug transporter organic anion transporting polypeptide 1B1 Is important for protein surface expression. Journal of Drug Delivery 2014 ISSN: 2090-3014 eISSN: 2090-3014
    • Meredith, D. (2012). Intestinal physiology amongst the dreaming spires: the 24th EITG meeting, 4-7th September 2011, Oxford, UK. Genes and Nutrition 6 pp.3-4
    • Taylor-Wells, J.C., Meredith, D. and Kelly, S. Structural determination of Oatp transporters utilising homology models and cell based assays. Faseb Journal 26 (2012) 
    • Suhre, K., Shin, S.Y., Petersen, A.K., Mohney, R.P., Meredith, D., Wägele, B., Altmaier, E., CARDIoGRAM, Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C.J., de Angelis, M.H., Kastenmüller, G., Köttgen, A., Kronenberg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H.W., Milburn, M.V., Prehn, C., Raffler, J., Ried, J.S., Römisch-Margl, W., Samani, N.J., Small, K.S., Wichmann, H.E., Zhai, G., Illig, T., Spector, T.D., Adamski, J., Soranzo, N. and Gieger, C. (2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477, 54-60.
    • Pillai, S.M. and Meredith, D. (2011). SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. Journal of Biological Chemistry, 286, 2455-2460.
    • Pieri, M., Christian, H.C., Wilkins, R.J., Boyd, C.A.R. and Meredith, D. (2010). The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. American Journal of Physiology, 299, G136-G143.
    • Foley, D.W., Rajamanickam, J., Bailey, P.D. and Meredith, D. (2010). Bioavailability through PepT1: the role of computer modelling in intelligent drug design. Current Computer-Aided Drug Design, 6, 68-78.
    • Foley, D., Pieri, M., Pettecrew, R., Price, R., Miles, S., Lam, H.K., Bailey, P. and Meredith, D. (2009). The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transorter, PepT1. Organic Biomolecular Chemistry, 7, 3652-3656.
    • Pieri, M., Gan, C., Bailey, P. and Meredith, D. (2009). The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1. International Journal of Biochemistry and Cell Biology, 41, 2304-2313.
    • Wilson, M.C., Meredith, D., Bunnun, C., Sessions, R.B. and Halestrap, A.P. (2009). Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. Journal of Biological Chemistry, 284(30) DOI:10.1074/jbc.M109.014217.
    • Bailey, P.D., Foley, D.W., Pieri, M. and Meredith, D. (2009). Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1. Organic and Biomolecular Chemistry, 7, 1064-1067.
    • Meredith, D. (2009). The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence? Philosophical Transactions of The Royal Society London B, 364, 203-7.
    • Mace, O.J., Lister, N., Morgan, E., Shepherd, E., Affleck, J., Helliwell, P., Bronk, J.R., Kellett, G.L., Meredith, D., Boyd, C.A.R., Pieri, M., Bailey, P.D., Pettecrew, R. and Foley, D. (2009). An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. Journal of Physiology 587, 195-210.
    • Meredith, D. and Christian, H.C. (2008). The SLC16 monocarboxylate transporter family. Xenobiotica. 38, 1072-1106.
    • Pieri, M., Hall, D., Collins, T., Bailey, P.D. and Meredith, D. (2008). Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1. International Journal of Biochemistry and Cell Biology, 40, 721-730.
    • Meredith, D., Gehl, K.A., Seymour, J., Ellory, J.C. and Wilkins, R.J. (2007). Characterisation of sulphate transporters in articular chondrocytes. Journal of Orthopaedic Research, 25, 1145-1153.
    • Solomon, D.H., Wilkins, R.J., Meredith, D. and Browning, J.A. (2007). Characterisation of inorganic phosphate transport in bovine articular chondrocytes. Cellular Physiology and Biochemistry, 20, 99-108.
    • Wilson, C., Vereshchagina, N., Reynolds, B., Meredith, D., Boyd, C.A.R. and Goberdhan, D.C.I. (2007). Extracellular and Subcellular Regulation of the PI3-kinase/Akt Cassette: New Mechanisms for Controlling Insulin and Growth Factor Signalling, Biochemical Society Transactions, 35, 219-221.
    • Bailey, P.D., Boyd, C.A.R., Collier, I.D., Kellett, G.L., Meredith, D., Morgan, K.M., Pettecrew, R. and Price, R.A. (2006). Affinity prediction for substrates of the peptide transporter PepT1. Chemical Communications 2006 (3), 323-5.
    • Meredith, D. and Boyd, C.A.R. (2006). Multimerisation – an only transporter is a lonely transporter. Physiology News 62 (The Physiological Society), 20-22.
    • Meredith, D. and Price, R.A. (2006). Molecular modelling of PepT1 – towards a structure. Journal of Membrane Biology, 213, 79-88.
    • Omer, S., Meredith, D., Morris, J.F. and Christian, H.C. (2006). evidence for the role of ABCA1 in the externalisation of annexin 1 from pituitary folliculo-stellate cells and ABCA1-transfected cell models. Endocrinology, 147, 3219-27.
    • Pantisas, K.E., Boyd, C.A.R. and Meredith, D. (2006). Evidence that rabbit PepT1 is a multimer when expressed in Xenopus laevis oocytes. Pflugers Archiv European Journal of Physiology, 452, 53-63.
    • Bailey, P.D., Boyd, C.A.R., Collier, I.D., Kellett, G.L., Meredith, D., Morgan, K.M., Pettecrew, R. and Price, R.A. (2005). Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter. Organic & Biomolecular Chemistry, 3, 4038-9.
    • Bailey, P.D., Boyd, C.A.R., Collier, I.D., Kellett, G.L., Meredith, D., Morgan, K.M., Pettecrew, R., Price, R.A. and Pritchard, R.G. (2005). Conformational and spatial preferences for substrates of PepT1. Chemical Communications 2005 (42), 5352-4.
    • Goberdhan, D.C.I., Meredith, D., Boyd, C.A.R. and Wilson, C. (2005). PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development, 132, 2365-2375.
    • Wilson, M.C., Meredith, D., Manning Fox, J.E., Manoharan, C., Davies, A.J. and Halestrap, A.P. (2005). Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is Embigin (gp70). Journal of Biological Chemistry, 280, 27213-21.
    • Halestrap, A.P. and Meredith, D. (2004). The SLC16 gene family - from Monocarboxylate Transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Archiv European Journal of Physiology, 447, 619-28.
    • Meredith, D. (2004). Site-directed mutation of arginine282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1. Journal of Biological Chemistry, 279, 15795-8.
    • Tattersall, A.L., Meredith, D., Shen, M-R., Ellory, J.C. and Wilkins, R.J. (2003). Molecular and functional identification of the Na+ ´ H+ exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes. Cellular Physiology and Biochemistry 13, 215-22.
    • Windhaber, R., Wilkins, R.J. and Meredith, D. (2003). Characterisation of glucose transport in bovine articular chondrocytes. Pflugers Archiv European Journal of Physiology, 446, 572-7.
    • Meredith, D., Bell, P., McClure, B. and Wilkins, R.J. (2002). Functional and molecular characterization of lactic acid transport in bovine articular chondrocytes. Cellular Physiology and Biochemistry 12, 227-234.
    • Pollard, M., Meredith, D. and McGivan, J.D. (2002). Identification of the plasma membrane glutamine transporter from the rat hepatoma cell line H4-II-E-C3. Biochemical Journal 368, 371-375.
    • Pollard, M., Meredith, D. and McGivan, J.D. (2002). Characterisation and cloning of a novel member of the system B°/ASC superfamily of amino acid transporters. Biochimica et Biophysics Acta 1561, 202-208.
    • Wilson, M.C., Meredith. D. and Halestrap, A.P. (2002). Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. Journal of Biological Chemistry, 277, 3666-3672.
    • Bailey, P.D., Boyd, C.A.R., Bronk, J.R., Collier, I.D., Meredith, D., Morgan, K.M. and Temple, C.S. (2000). How to make drugs orally active: a substrate template for peptide transporter PepT1. Angewandte Chemie International Edition 39, 506-508.
    • Manning Fox, J.E., Meredith, D. and Halestrap, A.P. (2000). The properties of monocarboxylate transporter isoform 4 (MCT4) expresses in Xenopus oocytes reflect its role in lactic acid efflux from skeletal muscle. Journal of Physiology, 529, 285-293.
    • Meredith, D. and Boyd, C.A.R. (2000). Structure and function of eukaryotic peptide transporters. Cellular and Molecular Life Sciences, 57 754-778.
    • Meredith, D., Temple, C.S., Guha, N., Sword, C.J. and Boyd, C.A.R. (2000). Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1. European Journal of Biochemistry 267, 3723-3728.
    • Meredith, D., Boyd, C.A.R., Bronk, J.R., Bailey, P.D., Morgan, K.M., Collier, I.D. and Temple, C.S. (1998). 4-Aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1. Journal of Physiology 512, 629-634.
    • Temple, C.S., Stewart, A.K., Meredith, D., Lister, N.A., Morgan, K.J., Collier, I.D., Vaughan-Jones, R.J., Boyd, C.A.R., Bailey, P.D. and Bronk, J.R. (1998). Peptide mimics as substrates for the intestinal peptide transporter. Journal of Biological Chemistry 273, 20-22.
    • Shirazi-Beechey, S., Meredith, D. and Boyd, C.A.R. (1997). An absorbing story: Transporting glucose and peptides into the body. The Wellcome Trust Review, 6.
    • Chen, S., Meredith, D. and Boyd, C.A.R. (1996). Both the H13 gene product and the 4F2 antigen are involved in the induction of system y+ cationic amino acid transport following activation of human peripheral blood mononuclear cells (PBM). Biochimica et Biophysica Acta, 1284, 1-3.
    • Meredith, D. and Laynes, R.W. (1996). Dipeptide transport in brush-border membrane vesicles (BBMV) prepared from human full-term placentae. Placenta 17, 173-179.
    • Meredith, D. and Boyd, C.A.R. (1995). Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes. American Journal of Physiology (Lung Cell and Molecular Physiology) 269, L137-43.
    • Meredith, D. and Boyd, C.A.R. (1995). Oligopeptide transport by epithelial cells. Journal of Membrane Biology 145, 1-12.
    • Helliwell, P.A., Meredith, D., Boyd, C.A.R., Bronk, J.R., Lister, N. and Bailey, P.D. (1994). Tripeptide transport in rat lung. Biochimica et Biophysica Acta 1190, 430-4.
    • Fervenza, F.C., Meredith, D., Ellory, J.C. and Hendry, B.M. (1991). Uridine transport in human erythrocytes: data from patients with renal failure. Experimental Physiology 76, 53-8.
    • Fervenza, F.C., Meredith, D., Ellory, J.C. and Hendry, B.M. (1991). A study of erythrocyte amino acid transport in patients with chronic renal failure. Nephrology, Dialysis & Transplantation 5, 594-9.
    • Fervenza, F.C., Meredith, D., Ellory, J.C. and Hendry, B.M. (1991). Abnormal erythrocyte choline transport in patients with chronic renal failure. Clinical Science 80, 137-141.
    • Book chapter


      • Bibby, K., Fervenza, F.C., Meredith, D., Ellory, J.C., Hendry, B.M. (1991). Altered membrane transport of choline in renal failure: a comparison of non-dialysed and haemodialysed patients. In: Andreucci VE, Dal Canton A, ed. ‘New Therapeutic Strategies in Nephrology’. Kluwer Academic Publishers, 289–292.
    • Book


      • Wilkins, R.J., Cross, S.S., Megson, I. and Meredith, D. (Eds). (2011). ‘Oxford Handbook of Medical Science, 2e’. Oxford University Press.