Department of Biological and Medical Sciences

Projects

  • Characterising the functional spectrum of the mosquito GABA receptor

    The insect GABA receptor is a known insecticide target. In several insect species, the GABA receptor undergoes RNA A-to-I editing, effectively generating species-specific variants that could not have been detected by looking at the genome sequence. We are using the mosquito GABA receptor to investigate the impact of species-specific RNA editing on receptor functional properties as well as sensitivity to insecticides.