Department of Biological and Medical Sciences

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  • Trypanosome Cell Biology

    Research in the Vaughan Lab focuses on the cell biology of Trypanosomes with a focus on the flagellum, which is an important organelle for pathogenicity in this parasite. This includes motility, immune evasion through motility and attachment to surfaces. Cilia and flagella are found in a wide variety of eukaryotic cells and defective function of these organelles are linked to a number of Human genetic diseases collectively called ciliopathies. We use a variety of cutting edge 3D microscopy techniques including serial block face scanning electron microscopy, array tomography, cellular electron tomography, cpnfocal airyscan and are involved in applications development.