INDEPTH Supported Publication and Cover Image

Friday, 06 November 2020


Ariadna Picart-Picolo, Frederic Pontvianne and colleagues have published a paper in Genome Research that was supported by the INDEPTH Cost Action.

The INDEPTH Cost Action supported this open access publication that included the cover image. This artwork is by Clément Costarella,, and was conceptually inspired by Frédéric Pontvianne). 

An explanation from Genome Research: An artistic representation of 3D genome organization, illustrating chromosome territories, nuclear compartments, as well as the emergence of structural variants due to genomic instability. In this issue, long-read sequencing in an Arabidopsis thaliana line with decreased ribosomal RNA (rRNA) gene copies shows features of genomic instability, including an accumulation of large tandem duplications, which lead to the duplication of hundreds of genes within a few generations. The authors investigate the impact of these duplications on 3D genome organization, gene expression, cytosine methylation, and plant phenotype, uncovering a potential link between these duplications and pathogen resistance.

Picart-Picolo A, Grob S, Picault N, Franek M, Llauro C, Halter T, Maier TR, Jobet E, Descombin J, Zhang P, Paramasivan V, Baum TJ, Navarro L, Dvořáčková M, Mirouze M, Pontvianne F (2020) Large tandem duplications affect gene expression, 3D organization, and plant-pathogen response. Genome Res. doi: 10.1101/gr.261586.120