Professor Dave Carter

Visiting Professor in Biomedical Science

Department of Biological and Medical Sciences

Role

Dave graduated from York University with a BSc in Biochemistry, which included a year working on the human genome project at the Sanger Institute in Cambridge. He completed his PhD at Cambridge University under the supervision of Dr Peter Fraser. During his PhD he developed a novel assay, ‘RNA-tagging and recovery of associated proteins’, to demonstrate a physical interaction between a locus control region and the β-globin gene. He then worked at Oxford University as a postdoctoral researcher in Prof Peter Cook’s lab, investigating the structure of transcription factories.

He was appointed as Senior Lecturer in Biomedical Science in October 2009 (and recently promoted to Professor) in the Faculty of Health and Life Sciences at Oxford Brookes University (OBU). Here he established a lab to study the effects of non-coding RNAs and extracellular vesicles in stress response.

In 2021, Dave took up a position as Research Director at Evox Therapeutics Ltd, an Oxford-based biotechnology company who are developing extracellular vesicles as therapeutic delivery vehicles for a range of rare diseases; he continues to be associated with Oxford Brookes as a Visiting Professor. 

Research

Cargo and delivery of extracellular vesicles
Extracellular vesicles (EVs) are small cargo-carrying vesicles that can be released by cells into the extracellular space. For many years it was thought that EVs were simply a route by which cells removed unwanted material, but it is now realised that they have a range of important functional roles and are part of the molecular dialogue that cells use to communicate. We are investigating how EVs are taken up by cells and how they are able to cause changes to the recipient cells.


Extracellular vesicles as mediators of intercellular stress response
Cells that have been stressed release factors that signal to neighbouring cells. These factors can be taken up by nearby cells triggering the appearance of DNA damage. Together with our collaborator, Prof Munira Kadhim, we have shown that extracellular vesicles are responsible for this so called "bystander effect". We now wish to characterise the contents of these vesicles and understand the mechanisms by which they can induce DNA damage in neighbouring cells.


The role of miRNAs and extracellular vesicles in regulating drug resistance in cancer
Many forms of cancer can be treated with cytotoxic drugs. Such treatment is often successful in the first instance, but the cancer usually evolves and often returns as a drug resistant tumour. We are interested in characterising the changes in miRNA expression and extracellular vesicle function that occur as cancer cells acquire drug resistance. More importantly we want to test whether perturbing miRNAs or modifying vesicles can induce or reverse the resistance to cytotoxic drugs such as cisplatin.

Projects as Principal Investigator, or Lead Academic if project is led by another Institution

  • Oxford BBSRC DTP 20-21 (led by University of Oxford) (01/09/2020 - 31/08/2024), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £127,124
  • BBSRC DTP - Round 5 - 3 Studentships - 19/20 start (16/09/2019 - 15/09/2023), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £149,496
  • ExoPop: Extracellular Vesicle Profiling for early detection of leukaemic progression (01/12/2018 - 31/12/2020), funded by: Cancer Research UK, funding amount received by Brookes: £56,981
  • BBSRC DTP - Round 4 - 1 Studentship - 18/19 start (17/09/2018 - 16/09/2022), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £49,234
  • BBSRC DTP - Round 3 - 2 Studentships - 17/18 start (01/10/2017 - 30/09/2021), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £96,912
  • The use of super-resolution microscopy to analyse delivery of extracellular vesicle cargo (18/09/2017 - 17/09/2022), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £98,212
  • Elizabeth Dellar DTP consumables (01/07/2017 - 30/09/2020), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £15,000
  • Elucidating the mechanisms and pathways of extracellular vesicle uptake (26/06/2017 - 31/12/2020), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £452,093
  • 2 Research Studentships - BBSRC DTP 2016/17 start (19/09/2016 - 18/09/2020), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £95,712

Projects as Co-investigator

  • Extension to research collaboration with Porton Biopharma(15/11/2019 - 31/03/2021), funded by: Porton Biopharma Limited, funding amount received by Brookes: £50,000, funded by: Porton Biopharma Limited
  • Investigating the role of extracellular vesicles in baculovirus replication(01/10/2019 - 31/03/2023), funded by: Oxford Expression Technologies Ltd, funding amount received by Brookes: £41,879, funded by: Oxford Expression Technologies Ltd

Publications

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