Staff Profiles

Professor David Fell

Professor of Systems Biology

Department of Biological and Medical Sciences

Faculty of Health and Life Sciences


After studying biochemistry at Oxford University, followed by a DPhil on the physical biochemistry of yeast pyruvate kinase, David started lecturing at Oxford Polytechnic. His research gradually moved from experimental biochemistry into computer simulation and theoretical analysis of metabolic control, and he has written the only textbook on metabolic control analysis, Understanding the Control of Metabolism. In 2001, he helped to found and became part-time Chief Scientific Officer of the Oxford company, Physiomics plc, which is using computer simulation of cellular systems for the development and analysis of therapeutic strategies for the pharmaceutical industry.

Physiomics has firmly established itself as a leading light in systems biology approaches to drug discovery and latterly in therapy design, demonstrable through contracts with three major international pharmaceutical companies. Through its strong advocacy of this approach the sector has invested in and adopted new computational biology processes. As Physiomics has continued to grow, it has expanded its own specialist research team, in many cases recruiting scientists trained within Fell’s Brookes-based research group at Brookes.

David is chairman of the Policy Committee of the Biochemical Society, and has been a member of several panels and committees of the Biotechnology and Biological Sciences Research Council.