Research in the Vaughan Lab focuses on the cell biology of Trypanosomes with a focus on the flagellum, which is an important organelle for the pathogenicity in this parasite. This includes motility, immune evasion through motility and attachment to surfaces. Cilia and flagella are found in a wide variety of eukaryotic cells and defective function of these organelles are linked to a number of Human genetic diseases collectively called ciliopathies.
We use a variety of cutting edge 3D microscopy techniques including serial block face scanning electron microscopy (SBF-SEM), array tomography, cellular electron tomography, confocal airyscan and are involved in applications development. Sue is also Director of Oxford Brookes Centre for Bioimaging /bioimaging/ and collaborates with a wide variety of parasitolgists.
Research grants and awards
Academy of Medical Sciences networking grant (2019-2020). TsetseNET: Developing scientific capacity through an interdisciplinary international network for tsetse fly research (~£25K).
The Wellcome Trust Collaborative Grant (2016-2021): TrypTag – a genome-wide localisation study (University of Oxford, Oxford Brookes, University of Cambridge, University of Liverpool) (~750K).
MRC Research Grant (2015-2019) Structure/Function relationships in protozoan parasites utilising high resolution 3D bioimaging ~£320K (MR/N017323/1).
BBSRC responsive mode grant award (2014-2019). Using SBEM and cellular electron tomography to study the basal body/pro-basal body linker ~£600K. (BB/M000532/1).
BBSRC Alert 13 grant award (2013). The Oxford consortium for three dimensional electron microscopy ~£698K. (BB/L014122/1).
BBSRC New Investigator award (2011-14). Three dimensional cellular electron microscopy of eukaryotic basal bodies ~£450K (BB/I000402/1).