My laboratory is interested in gene diversity and the resulting functional/pharmacological properties of ligand-gated ion channels, using genome sequence analysis, molecular biology and electrophysiology. In particular, I am focusing on cys-loop ligand-gated ion channels of insects. The cys-loop ligand-gated ion channel superfamily includes nicotinic acetylcholine receptors, GABA receptors and glutamate-gated chloride channels, which play key roles in signalling and are also of interest as they are targets of pesticides. I am also interested in investigating changes (commonly mutations) in cys-loop ligand-gated ion channels that give rise to pesticide resistance.
Research group membership
REF Group: UoA5: Biomedicine, Cell and Developmental Biology, Ecology and Evolution, Genetics and Genomics
- Dr Andrew Jones, Research Group Leader
- Eleanor Mitchell, PhD Student
- Jay Hands, PhD Student, joint supervision with Dr Casper Breuker
Research grants and awards
BBSRC Oxford Doctoral Training Program iCASE studentship 2018-2022
Oxford Brookes Research Excellence Award 2017
Nigel Groome PhD Studentship 2015-2018
Higher Education Innovation Funding (HEIF), Oxford Brookes University, 2014
The Leverhulme Trust RPG-2012-602: 'Characterising the functional spectrum of the mosquito GABA receptor'.
Characterisation of insect cys-loop ligand-gated ion channels including the GABA receptor, RDL, and nicotinic acetylcholine receptors.
Investigating target-site insecticide resistance in mosquitoes from Laos.