Research group membership
Regulation of Gene Expression
We are made up of cells that differ dramatically in their size, shape, function, longevity and ability to keep dividing even though, with few exceptions, every cell contains the same genome. The great diversity of cells observed in an adult human is a consequence of the different cell types expressing different profiles of genes. Failure of correct gene regulation during foetal development usually results in death or severe congenital defects, and in adult life leads to disease including cancer.
My research group uses a combination of Drosophila genetics, molecular biology, biochemistry and immunohistochemistry to study the mechanisms that transcription factors use to regulate gene expression during animal development.