Dr David Meredith

MA DPhil, Fellow of the HEA

Senior Lecturer in Biochemistry / Biomedical Science

School of Biological and Medical Sciences

dmeredith@brookes.ac.uk

Role

I am the Subject co-ordinator for BSc Biological Sciences; I am also Knowledge Exchange Lead for the Faculty of Health & Life Sciences.

Areas of expertise

Membrane transporter protein structure and function (expression and transport assays), including characterising 'orphan' transporters.
Design, synthesis and biological testing of novel peptidic prodrug molecules (in collaboration with Prof Pat Bailey, London South Bank University and Dr David Foley, University of Cardiff)

Teaching and supervision

Courses

Modules taught

I teach on a number of modules in the Biomedical and Biological Sciences area, from 1st year onwards, including Scientific Skills, Introduction to Biochemistry A & B, Biochemistry of Cell Function, Molecular Medicine and Evidence Based Medicine & Diagnostics.

I also supervise undergraduate project students.

Supervision

I have supervised six students to PhD completion.

Research

I lead the Membrane Transport Group research group. We investigate the structure-function relationship of membrane transport proteins, to try to elucidate how they bind and transport their substrates. In particular, we study (nutrient) transporters that are naturally present in the intestine with a view to designing small drug molecules that can be taken up through them. These transporters include the peptide transporter (PepT1), amino acid transporters (the PAT family), monocarboxylate transporters (MCTs) and organic anion transporters (OATPs).

The techniques involved range from expression of wild-type and mutated transporter proteins in model systems, cell culture, medicinal chemistry (with Prof Pat Bailey, London South Bank University & Dr David Foley, University of Cardiff) and protein crystallography and molecular modelling (with Dr Newstead and Prof Samson's groups, respectively, University of Oxford).

Groups

Membrane Transport Research

Publications

Harris SE, Blasio MJ, Zhao X, Ma M, Davies KL, Wooding FBP, Hamilton RS, Blache D, Meredith D, Murray AJ, Fowden AL, Forhead AJ, Thyroid deficiency before birth alters the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity
Thyroid 30 (6) (2020) pp.794-805 ISSN: 1050-7256 eISSN: 1557-9077) Thyroid deficiency before birth alters the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity Open Access version on RADAR
Foley DW, Pathak RB, Phillips TR, Wilson GL, Bailey PD, Pieri M, Senan A, Meredith D, Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery
European Journal of Medicinal Chemistry 156 (2018) pp.180-189 ISSN: 0223-5234 eISSN: 1768-3254 Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery Open Access version on RADAR
Harris SE, De Blasio MJ, Davis MA, Kelly A, Davenport HM, Wooding FBP, Blache D, Meredith D, Anderson M, Fowden AL, Limesand SW, Forhead AJ, Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation
The Journal of Physiology 595 (11) (2017) pp.3331-3343 ISSN: 0022-3751 eISSN: 1469-7793 Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation Open Access version on RADAR
Foley DW, Bermudez I, Bailey PD, Meredith D, A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1
MedChemComm 2016 (7) (2016) pp.999-1002 ISSN: 2040-2503
Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MS, Tucker SJ, Meredith D, Fowler PW, Newstead S, Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
Structure 23 (10) (2015) pp.1889-1899 ISSN: 0969-2126
Taylor-Wells J, Meredith D, The signature sequence region of the human drug transporter organic anion transporting polypeptide 1B1 Is important for protein surface expression
Journal of Drug Delivery 2014 (2014) ISSN: 2090-3014
Meredith D, Intestinal physiology amongst the dreaming spires: the 24th EITG meeting, 4-7th September 2011, Oxford, UK
Genes & Nutrition 6 (2012) pp.3-4 ISSN: 1555-8932
Taylor-Wells JC, Meredith D, Kelly S, Structural Determination of Oatp Transporters Utilising Homology Models and Cell Based Assays
The FASEB Journal 26 (2012) ISSN: 0892-6638 eISSN: 1530-6860
Suhre K, Shin S, Petersen A, Mohney R, Meredith D, Wagele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond C, de Angelis M, Kastenmuller G, Kottgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes H, Milburn M, Prehn C, Raffler J, Ried J, Romisch-Margl W, Samani N, Small K, Wichmann H, Zhai G, Illig T, Spector T, Adamski J, Soranzo N, Gieger C, Human metabolic individuality in biomedical and pharmaceutical research
Nature 477 (7362) (2011) pp.54-60 ISSN: 0028-0836 eISSN: 1476-4687
Foley D, Rajamanickam J, Bailey P, Meredith D, Bioavailability Through PepT1: The Role of Computer Modelling in Intelligent Drug Design
Current Computer Aided-Drug Design 6 (1) (2010) pp.68-78 ISSN: 1573-4099
Pillai S, Meredith D, SLC36A4 (hPAT4) Is a High Affinity Amino Acid Transporter When Expressed in Xenopus laevis Oocytes
Journal of Biological Chemistry 286 (4) (2010) pp.2455-2460 ISSN: 0021-9258 eISSN: 1083-351X
Taylor-Wells JC, Meredith D, Kelly S, Structural Determination of OATP Transporters Utilising Homology Models and Cell Based Assays
The FASEB Journal 24 (1) (2010) ISSN: 0892-6638 eISSN: 1530-6860
Pieri M, Christian H, Wilkins R, Boyd C, Meredith D, The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase
American Journal of Physiology - Gastrointestinal and Liver Physiology 299 (1) (2010) pp.G136-G143 ISSN: 0193-1857 eISSN: 1522-1547
Wilson MC, Meredith D, Bunnun C, Sessions RB, Halestrap AP, Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle
Journal of Biological Chemistry 284 (2009) pp.20011-20021 ISSN: 0021-9258 eISSN: 1083-351X
Mace O, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk J, Kellett G, Meredith D, Boyd R, Pieri M, Bailey P, Pettcrew R, Foley D, An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine.
The Journal of Physiology 587 (1) (2009) pp.195-210 ISSN: 0022-3751
Wilson M, Meredith D, Bunnun C, Sessions R, Halestrap A, Studies on the DIDS binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle
Journal of Biological Chemistry 284 (30) (2009) pp.20011-20021 ISSN: 0021-9258
Foley D, Bailey P, Pieri M, Meredith D, Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1
Organic and Biomolecular Chemistry 7 (6) (2009) pp.1064-1067 ISSN: 1477-0520
Foley D, Pieri M, Pettecrew R, Price R, Miles S, Lam H, Bailey P, Meredith D, The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1
Organic and Biomolecular Chemistry 7 (18) (2009) pp.3652-3656 ISSN: 1477-0520
Meredith D, The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence?
Philosophical Transactions of the Royal Society B: Biological Sciences 364 (1514) (2009) pp.203-207 ISSN: 0962-8436 eISSN: 1471-2970
Pieri M, Gan C, Bailey P, Meredith D, The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1
The International Journal of Biochemistry and Cell Biology 41 (11) (2009) pp.2204-2213 ISSN: 1357-2725
Pieri M, Hall D, Price R, Bailey P, Meredith D, Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1
The International Journal of Biochemistry and Cell Biology 40 (4) (2008) pp.721-730 ISSN: 1357-2725
Meredith D, Christian H, The SLC16 monocaboxylate transporter family
Xenobiotica: the fate of foreign compounds in biological systems 38 (41128) (2008) pp.1072-1106 ISSN: 0049-8254 eISSN: 1366-5928
Meredith D, Gehl KA, Seymour J, Ellory JC, Wilkins RJ, Characterization of sulphate transporters in isolated bovine articular chondrocytes
Journal of Orthopaedic Research 25 (9) (2007) pp.1145-1153 ISSN: 0736-0266 eISSN: 1554-527X
Wilson C, Vereshchagina N, Reynolds B, Meredith D, Boyd CAR, Goberdhan DCI, Extracellular and subcellular regulation of the PI3K/Akt cassette: new mechanisms for controlling insulin and growth factor signalling
Biochemical Society Transactions 35 (2) (2007) pp.219-221 ISSN: 0300-5127 eISSN: 1470-8752
Solomon DH, Wilkins RJ, Meredith D, Browning JA, Characterisation of inorganic phosphate transport in bovine articular chondrocytes
Cellular Physiology and Biochemistry 20 (1-4) (2007) pp.99-108 ISSN: 1015-8987
Meredith D, Price RA, Molecular modeling of PepT1- Towards a structure
Journal of Membrane Biology 213 (2) (2006) pp.79-88 ISSN: 0022-2631 eISSN: 1432-1424
Omer S, Meredith D, Morris JF, Christian HC, Evidence for the role of adenosine 5 '-triphosphate-binding cassette (ABC)-A1 in the externalization of annexin 1 from pituitary folliculostellate cells and ABCA1-transfected cell models
Endocrinology 147 (7) (2006) pp.3219-3227 ISSN: 0013-7227 eISSN: 1945-7170
Panitsas KE, Boyd CAR, Meredith D, Evidence that the rabbit proton-peptide co-transporter PepT1 is a multimer when expressed in Xenopus laevis oocytes
Pflügers Archiv European Journal of Physiology 452 (1) (2006) pp.53-63 ISSN: 0031-6768 eISSN: 1432-2013
Bailey PD, Boyd CAR, Collier ID, George JP, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA, Affinity prediction for substrates of the peptide transporter PepT1
Chemical Communications 2006 (3) (2006) pp.323-325 ISSN: 1359-7345 eISSN: 1364-548X
Bailey PD, Boyd CAR, Collier ID, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA, Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter
Organic and Biomolecular Chemistry 3 (2005) pp.4038-4039 ISSN: 1477-0520 eISSN: 1477-0539
Wilson MC, Meredith D, Fox JEM, Manoharan C, Davies AJ, Halestrap AP, Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4 - The ancillary protein for the insensitive MCT2 is embigin (gp70)
Journal of Biological Chemistry 280 (2005) pp.27213-27221 ISSN: 0021-9258 eISSN: 1083-351X
Goberdhan DCI, Meredith D, Boyd CAR, Wilson C, PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
Development 132 (2005) pp.2365-2375 ISSN: 0950-1991 eISSN: 1477-9129
Bailey PD, Boyd CAR, Collier ID, George JG, Kellett GL, Meredith D, Morgan KM, Pettecrew R, Price RA, Pritchard RG, Conformational and spacial preferences for substrates of PepT1
Chemical Communications 2005 (42) (2005) pp.5352-5354 ISSN: 1359-7345 eISSN: 1364-548X
Meredith D, Site-directed mutation of arginine 282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1
Journal of Biological Chemistry 279 (2004) pp.15795-15798 ISSN: 0021-9258 eISSN: 1083-351X
Halestrap AP, Meredith D, The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
Pflügers Archiv European Journal of Physiology 447 (5) (2004) pp.619-628 ISSN: 0031-6768 eISSN: 1432-2013
Windhaber RAJ, Wilkins RJ, Meredith D, Functional characterisation of glucose transport in bovine articular chondrocytes
Pflügers Archiv European Journal of Physiology 446 (5) (2003) pp.572-577 ISSN: 0031-6768 eISSN: 1432-2013
Tattersall AL, Meredith D, Furla P, Shen MR, Ellory JC, Wilkins RJ, Molecular and functional identification of the Na+/H+ exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes
Cellular Physiology and Biochemistry 13 (4) (2003) pp.215-222 ISSN: 1015-8987
Pollard M, Meredith D, McGivan JD, Identification of a plasma membrane glutamine transporter from the rat hepatoma cell line H4-IIE-C3
Biochemical Journal 368 (1) (2002) pp.371-375 ISSN: 0264-6021 eISSN: 1470-8728
Meredith D, The N-terminal blocked amino acid N-acetyl-L-phenylalanine is a non-translocated substrate for the mammalian peptide transporter PepT1 expressed in Xenopus laevis oocytes
The Journal of Physiology 544 (S090) (2002) pp.91P-92P ISSN: 0022-3751 eISSN: 1469-7793
Pollard M, Meredith D, McGivan JD, Characterisation and cloning of a Na+-dependent broad-specificity neutral amino acid transporter from NBL-1 cells: a novel member of the ASC/B-0 transporter family
Biochimica et Biophysica Acta (BBA) - Biomembranes 1561 (2) (2002) pp.202-208 ISSN: 0005-2736
Wilson MC, Meredith D, Halestrap AP, Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ
Journal of Biological Chemistry 277 (2002) pp.3666-3672 ISSN: 0021-9258 eISSN: 1083-351X
Meredith D, Pollard M, McGivan JD, Functional characterization of the NBL-1 B-0 clone expressed in Xenopus oocytes: a new member of the ASC/B-0 family of amino acid transporters
The Journal of Physiology 539P (S061) (2002) pp.9P-9P ISSN: 0022-3751 eISSN: 1469-7793
Meredith D, Bell P, McClure B, Wilkins R, Functional and molecular characterisation of lactic acid transport in bovine articular chondrocytes
Cellular Physiology and Biochemistry 12 (4) (2002) pp.227-234 ISSN: 1015-8987
Meredith D, Halestrap AP, OX47 (basigin) may act as a chaperone for expression of the monocarboxylate transporter MCT1 at the plasma membrane of Xenopus laevis oocytes
The Journal of Physiology 526P (2000) pp.23P-24P ISSN: 0022-3751 eISSN: 1469-7793
Meredith D, Temple CS, Guha N, Sword CJ, Boyd CAR, Collier ID, Morgan KM, Bailey PD, Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1
European Journal of Biochemistry 267 (12) (2000) pp.3723-3728 ISSN: 0014-2956 eISSN: 1432-1033
Meredith D, Boyd CAR, Structure and function of eukaryotic peptide transporters
Cellular and Molecular Life Sciences 57 (5) (2000) pp.754-778 ISSN: 1420-682X eISSN: 1420-9071
Bailey PD, Boyd CAR, Bronk JR, Collier ID, Meredith D, Morgan KM, Temple CS, How to make drugs orally active: A substrate template for peptide transporter PepT1
Angewandte Chemie International Edition 39 (3) (2000) pp.505-508 ISSN: 1433-7851 eISSN: 1521-3773
Meredith D, Boyd CAR, Bronk JR, Bailey PD, Morgan KM, Collier ID, Temple CS, 4-aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1
The Journal of Physiology 512 (3) (1998) pp.629-634 ISSN: 0022-3751 eISSN: 1469-7793
Temple CS, Stewart AK, Meredith D, Lister NA, Morgan KM, Collier ID, Vaughan-Jones RD, Boyd CAR, Bailey PD, Bronk JR, Peptide mimics as substrates for the intestinal peptide transporter
Journal of Biological Chemistry 273 (1998) pp.20-22 ISSN: 0021-9258 eISSN: 1083-351X
Chen S, Meredith D, Boyd CAR, Both the H13 gene product and 4F2 antigen are involved in the induction of system y(+) cationic amino-acid transport following activation of human peripheral blood mononuclear cells (PBM)
Biochimica et Biophysica Acta (BBA) - Biomembranes 1284 (1996) pp.1-3 ISSN: 0005-2736
Meredith D, Laynes RW, Dipeptide transport in brush-border membrane vesicles (BBMV) prepared from human full-term placentae
Placenta 17 (1996) pp.173-179 ISSN: 0143-4004 eISSN: 1532-3102
MEREDITH D, BOYD CAR, DIPEPTIDE TRANSPORT CHARACTERISTICS OF THE APICAL MEMBRANE OF RAT LUNG TYPE-II PNEUMOCYTES
American Journal of Physiology - Lung Cellular and Molecular Physiology 269 (1995) pp.L137-L143 ISSN: 1040-0605 eISSN: 1522-1504
HELLIWELL PA, MEREDITH D, BOYD CAR, BRONK JR, LISTER N, BAILEY PD, TRIPEPTIDE TRANSPORT IN RAT LUNG
Biochimica et Biophysica Acta (BBA) - Biomembranes 1190 (1994) pp.430-434 ISSN: 0005-2736
Fervenza FC, Meredith D, Ellory JC, Hendry BM, ABNORMAL ERYTHROCYTE CHOLINE TRANSPORT IN PATIENTS WITH CHRONIC-RENAL-FAILURE
Clinical Science 80 (1991) pp.137-141 ISSN: 0143-5221 eISSN: 1470-8736
FERVENZA FC, MEREDITH D, ELLORY JC, HENDRY BM, URIDINE TRANSPORT IN HUMAN ERYTHROCYTES - DATA FROM NORMAL SUBJECTS AND FROM PATIENTS WITH RENAL-FAILURE
Experimental Physiology 76 (1) (1991) pp.53-58 ISSN: 0958-0670 eISSN: 1469-445X
Fervenza FC, Meredith D, Ellory JC, Hendry BM, A Study of the Membrane Transport of Aminoacids in Erythrocytes from Patients on Haemodialysis
Nephrology Dialysis Transplantation 5 (8) (1990) pp.594-599 ISSN: 0931-0509 eISSN: 1460-2385

Wilkins R, Megson I, Meredith D, (ed.), Oxford Handbook of Medical Sciences ,
Oxford University Press (2021) ISBN: 9780198789895
Wilkins,Robert; Cross, Simon; Megson, Ian, Oxford Handbook of Medical Sciences,
Oxford University Press (2011) ISBN: 978-0199588442

Foley DW, Bailey PD, Price RA, Meredith D, Pettecrew R, Improving Drug Oral Bioavailability By Targeting Pept1
236 (2010)

Manning Fox JM, Meredith D, Halestrap AP, The kinetics, and substrate and inhibitor specificities of human monocarboxylate tranporter 4 expressed in Xenopus laevis oocytes,
(2000)
Meredith D, Boyd CAR, Functional evidence that rabbit PepT1 may act as a multimer when expressed in Xenopus laevis oocytes,
(1998)
Meredith D, Temple CS, Boyd CAR, Kinetic evidence that neutral and anionic peptides bind to different conformations of the recombinant epithelial peptide transporter PepT1,
(1998)
Temple CS, Meredith D, Boyd CAR, Dipeptide transport by rat renal cortex BBMV is mediated by PepT1; functional analysis using ACE inhibitors,
(1997)
Meredith D, Boyd CAR, His(57) is an essential residue for the transport of the anionic dipeptide D-Phe-L-Glu by PepT1 expressed in Xenopus laevis oocytes,
(1996)
Meredith D, Temple CS, Boyd CAR, Chemical evidence for the involvement of histidine residues in proton-peptide co-transport by PepT1 expressed in Xenopus laevis oocytes,
(1996)
MEREDITH D, DIPEPTIDE TRANSPORT BY HUMAN PLACENTAL BRUSH-BORDER MEMBRANE-VESICLES (BBMV),
(1995)
MEREDITH D, BOYD CAR, OLIGOPEPTIDE TRANSPORT BY EPITHELIAL-CELLS,
(1995)
MEREDITH D, BOYD CAR, PEPTIDE-TRANSPORT IN TYPE-II PNEUMOCYTES FRESHLY ISOLATED FROM RAT LUNG,
(1993)

Professional information

Memberships of professional bodies

Member of The Physiological Society and the European Intestinal Transport Group
Fellow of the Higher Education Academy
School of Biological and Medical Sciences - Faculty of Health and Life Sciences