Professor Isabel Bermudez-Diaz
Professor in Neuropharmacology
School of Biological and Medical Sciences

Role
Areas of expertise
- Pharmacology of ligand-gated ion channels
- Electrophysiological recordings from ligand gated ion channels expressed heterologously in Xenopus oocytes.
- The substituted cysteine scanning method applied to ion channels expressed in Xenopus oocytes
- Mutagenesis and concatenation of ligand gated ion channels
Teaching and supervision
Courses
Modules taught
- Clinical Biochemistry and Pharmacology (Double Honours Module)
- Molecular Medicine (Honours module)
- MSc Module Molecular Basis of Human Genetic Diseases
Supervision
I have surpervised more than 20 PhD student, whose work has focused on insect or human Cys loop ligand gated ion channels.
I am currently supervising two PhD students as a Director of studies and three others as a second supervisor.
Research
The Molecular Neuroscience research group in the School of Biological and Medical Sciences has a long-term interest in the structural and functional relationships of ligand-gated ion channels, with particular emphasis on human nicotinic acetylcholine receptors (nAChR) expressed in the central nervous system. These receptors have been implicated in a wide range of diseases of the brain, including Alzheimer’s and Parkinson’s diseases, Tourette syndrome, schizophremia, autism, drug addiction and attention deficit disorders, and are therefore high-quality targets for drug therapy.
The overall goal of the research is to map and identify functional sites in the receptors that help us to understand better the how these important molecules generates signals in the brain. These sites can provide new strategies to develop more specific and safer therapeutic drugs.
The techniques of molecular biology, in vitro functional studies using primary or clonal cell cultures, radioligand-binding assays and electrophysiological recordings from the ligand-gated ion channels are combined to provide a multidisciplinary approach to the topic.
Research grants and awards
- Leverhulme
- Brookes University Research Excellence Award
- Nigel Groome PhD sudentship awards
Research projects
Current Projects include:
- Characterisation of plant- and animal-derived compounds for probing the structure and function of nAChRs to provide new leads for the development of selective therapeutic substances.
- Mapping and identification of allosteric pathways in nicotinic receptors.
- Effects of RIC-3 polymorphisms on the expression of nicotinic acetylcholine receptors
Groups
Publications
Journal articles
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Graur A, Haymond A, Lee K H, Viscarra F, Russo P, Luchini A, Paige M, Bermudez I, Kabbani N
, Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein
ACS Chemical Neuroscience 15 (11) (2024) pp.2322-2333 ISSN: 1948-7193 eISSN: 1948-7193 Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein Open Access version on RADAR -
Rebecca Appiani, Franco Viscarra, Philip Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi , Selective potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor response by NS9283 analogues
ACS Chemical Neuroscience 15 (7) (2024) pp.1501-1514 ISSN: 1948-7193 eISSN: 1948-7193 Selective potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor response by NS9283 analogues Open Access version on RADAR -
Pradhan A, Mountford H, Peixinho J, Rea E, Epeslidou E, Scott JS, Cull J, Maxwell S, Webster R, Beeson D, Dong Y, Prekovic S, Bermudez I, Newbury DF, Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech
Cellular and Molecular Life Sciences 81 (2024) ISSN: 1420-682X eISSN: 1420-9071 Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech Open Access version on RADAR -
Viscarra F, Chrestia JF, Sanchez Y, Pérez E, Biggin PC, Bouzat C, Bermudez I, and López JJ, Side Groups Convert The α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator
ACS Chemical Neuroscience 14 (16) (2023) pp.2876-2887 ISSN: 1948-7193 eISSN: 1948-7193 -
Chrestia JF, Oliveira AS, Mulholland AJ, Gallagher T, Bermúdez I, Bouzat C, A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor
Molecular Neurobiology 59 (2022) pp.6076-6090 ISSN: 0893-7648 eISSN: 1559-1182 A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor Open Access version on RADAR -
Peixinho J, Toseeb U, Mountford HS, Bermudez I, Newbury DF, The effects of prenatal smoke exposure on language development- a systematic review
Infant and Child Development 31 (4) (2022) ISSN: 1522-7227 eISSN: 1522-7219 The effects of prenatal smoke exposure on language development- a systematic review Open Access version on RADAR -
Mitchell EL, Viscarra F, Bermudez I, Hawkins J, Goodchild JA, Jones AK , The Apis mellifera alpha 5 nicotinic acetylcholine receptor subunit expresses as a homomeric receptor that is sensitive to serotonin
Pesticide Biochemistry and Physiology 182 (2022) ISSN: 0048-3575 eISSN: 1095-9939 The Apis mellifera alpha 5 nicotinic acetylcholine receptor subunit expresses as a homomeric receptor that is sensitive to serotonin Open Access version on RADAR -
Oliveira ASF, Avila Ibarra A, Bermudez I, Casalino L, Gaieb Z, Shoemark DK, Gallager T, Sessions RB, Amaroe RE, Mulholland A, A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors
Biophysical Journal 120 (2021) pp.983-993 ISSN: 0006-3495 eISSN: 1542-0086 A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors Open Access version on RADAR -
Minguez-Viñas T, E. Nielsen BE, Shoemark DK, Gotti C, Sessions RB, Mulhollad AJ, Bouza C, Wonnacott S, Gallagher T, Bermudez I, Oliveira AS, A conserved arginine with non-conserved function is a key determinant of agonist selectivity in alpha7 nicotinic acetylcholine receptors
British Journal of Pharmacology 178 (7) (2021) pp.1651-1668 ISSN: 0007-1188 eISSN: 1476-5381 A conserved arginine with non-conserved function is a key determinant of agonist selectivity in alpha7 nicotinic acetylcholine receptors Open Access version on RADAR -
Oliveira AS, Edsall C, Woods C, Bates P, Nunez G, Wonnacott S, Bermudez I, Ciccotti G, Gallagher T, Sessions R, Mulholland A, A general mechanism for signal propagation in the nicotinic acetylcholine receptor family
Journal of the American Chemical Society 141 (51) (2019) pp.19953-19958 ISSN: 0002-7863 A general mechanism for signal propagation in the nicotinic acetylcholine receptor family Open Access version on RADAR -
Quiroz G, Sotomayor-Zárate R, González-Gutierrez JP, Vizcarra F, Moraga F, Bermudez I, Reyes-Parada M, Quintanilla ME, Lagos D, Rivera-Meza M, Iturriaga-Vásquez P, UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats
Frontiers in Pharmacology 10 (2019) ISSN: 1663-9812 eISSN: 1663-9812 UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats Open Access version on RADAR -
Bermudez I, Neilsen BA, Bouzat C, Flavonoids as positive allosteric modulators of α7 nicotinic receptors
Neuropharmacology 160 (2019) ISSN: 0028-3908 eISSN: 1873-7064 Flavonoids as positive allosteric modulators of α7 nicotinic receptors Open Access version on RADAR -
Mazzaferro S, Bermudez I, Sine SM, Potentiation of a Neuronal Nicotinic Receptor via Pseudo-agonist Site
Cellular and Molecular Life Sciences 76 (6) (2019) pp.1151-1167 ISSN: 1420-682X eISSN: 1532-1991 Potentiation of a Neuronal Nicotinic Receptor via Pseudo-agonist Site Open Access version on RADAR -
Mazzaferro S, Bermudez I, Sine SM, Potentiation of a Neuronal Nicotinic Receptor via Pseudo-agonist Site
Cellular and Molecular Life Sciences 76 (6) (2019) pp.1151-1167 ISSN: 1420-682X eISSN: 1532-1991 Potentiation of a Neuronal Nicotinic Receptor via Pseudo-agonist Site Open Access version on RADAR -
Hugo Rego Campello, Silvia Garcia Del Villar, Aurélien Honraedt,Teresa Minguez Viñas, A. Sofia F. Oliveira,Kara E. Ranaghan, Deborah K. Shoemark, Isabel Bermudez,[Cecilia Gotti, Richard B. Sessions,Adrian J. Mulholland, Susan Wonnacott and Timothy Gallagher, Unlocking Nicotinic Selectivity via Direct C‒H Functionalisation of (‒)-Cytisine
Chem 4 (7) (2018) pp.1710-1725 ISSN: 2451-9294 Unlocking Nicotinic Selectivity via Direct C‒H Functionalisation of (‒)-Cytisine Open Access version on RADAR -
Neilsen BE, Minguez T, Bermudez I, Bouzat C, Molecular function of the novel α7β2 nicotinic receptor
Cellular and Molecular Life Sciences 75 (13) (2018) pp.2457-2471 ISSN: 1420-682X eISSN: 1532-1991 Molecular function of the novel α7β2 nicotinic receptor Open Access version on RADAR -
Taylor-Wells J, Senan A, Bermudez I, Jones AK, Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin
Insect Biochemistry and Molecular Biology 93 (2018) pp.1-11 ISSN: 0965-1748 Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin Open Access version on RADAR -
García-Bea A, Bermudez-Diaz I, Harrison PJ, Lane TA, A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
Journal of Psychopharmacology 31 (12) (2017) pp.1519-1526 ISSN: 0269-8811 A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding Open Access version on RADAR -
New K, Garcia Del Villar S, Mazzaferro S, Alcaino C, Bermudez I, The fifth subunit of the (α4β2)2β2 nicotinic acetylcholine receptor modulates maximal ACh responses
British Journal of Pharmacology 175 (11) (2017) pp.1822-1837 ISSN: 0007-1188 eISSN: 1476-5381 The fifth subunit of the (α4β2)2β2 nicotinic acetylcholine receptor modulates maximal ACh responses Open Access version on RADAR -
Mazzaferro S, Bermudez I, Sine SM, alpha4beta2 nicotinic acetylcholine receptors: relationships between subunit stoichiometry and function at the single channel level
Journal of Biological Chemistry 292 (2016) pp.2729-2740 ISSN: 0021-9258 eISSN: 1083-351X alpha4beta2 nicotinic acetylcholine receptors: relationships between subunit stoichiometry and function at the single channel level Open Access version on RADAR -
Alcaino C, Musgaard M, Minguez T, Mazzaferro S, Faundez M, Iturriaga-Vasquez P, Biggin PC, Bermudez I, Role of the Cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
Journal of Biological Chemistry 292 (2) (2016) pp.551-562 ISSN: 0021-9258 eISSN: 1083-351X Role of the Cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors Open Access version on RADAR -
Mangan D, McNabola N, Clark EH, Bermudez I, Wonnacott S, Southern JM, A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties
Organic and Biomolecular Chemistry 46 (2016) pp.10787-10798 ISSN: 1477-0520 eISSN: 1477-0539 A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties Open Access version on RADAR -
Taylor-Wells J, Hawkins J, Colombo C, Bermudez I, Jones AK, Cloning and functional expression of intracellular loop variants of the honey bee (Apis mellifera) RDL GABA receptor
NeuroToxicology 60 (2016) pp.207-213 ISSN: 0161-813X Cloning and functional expression of intracellular loop variants of the honey bee (Apis mellifera) RDL GABA receptor Open Access version on RADAR -
Mazzaferro S, Bermudez I, Del Villar SG, New KK, The beta 2(+)/alpha 4(-) Interfaces of (alpha 4 beta 2) 2 alpha 4 Nicotinic Receptors Allosterically Contribute to Receptor Function
Biophysical Journal 110 (Supplement 1) (2016) pp.604A-604A ISSN: 0006-3495 eISSN: 1542-0086 -
Foley DW, Bermudez I, Bailey PD, Meredith D, A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1
MedChemComm 2016 (7) (2016) pp.999-1002 ISSN: 2040-2503 -
Sciaccaluga M, Moriconi C, Martinello K, Catalano M, Bermudez I, Stitzel JA, Maskos U, Fucile S, Crucial role of nicotinic α5 subunit variants for Ca(2+) fluxes in ventral midbrain neurons
The FASEB Journal 29 (8) (2015) pp.3389-3398 ISSN: 0892-6638 eISSN: 1530-6860 -
Taylor-Wells J, Brooke BD, Bermudez I, Jones AK, The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor
Journal of Neurochemistry 135 (4) (2015) pp.705-713 ISSN: 0022-3042 eISSN: 1471-4159 The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor Open Access version on RADAR -
Iturriaga-Vasquez P, Alzate-Morales J, Bermudez I, Varas R, Reyes-Parada M, Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacology
Pharmacological Research 101 (2015) pp.9-17 ISSN: 1043-6618 -
Mazzaferro S, Gasparri F, New K, Alcaino C, Faundez M, Iturriaga Vasquez P, Vijayan R, Biggin PC, Bermudez I., Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy.
Journal of Biological Chemistry 289 (2014) pp.21795-21806 ISSN: 0021-9258 eISSN: 1083-351X -
Jin X, Bermudez I, Steinbach JH, The nicotinic α5 subunit can replace either an acetylcholine-binding or nonbinding subunit in the α4β2* neuronal nicotinic receptor
Molecular Pharmacology 85 (1) (2014) pp.11-17 ISSN: 0026-895X -
Exley R, Clements MA, Hartung H, McIntosh JM, Franklin M, Bermudez I, Cragg SJ, Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens
European Journal of Neuroscience 38 (7) (2013) pp.3036-3043 ISSN: 0953-816X eISSN: 1460-9568 -
Faundez-Parraguez M, Farias-Rabelo N,Gonzalez-Gutierrez JP,Etcheverry-Berrios A,Alzate-Morales J,Adasme-Carreño F,Varas R,Bermudez I,Iturriaga-Vasquez P, Neonicotinic analogues: selective antagonists for α4β2 nicotinic acetylcholine receptors
Bioorganic & Medicinal Chemistry 21 (10) (2013) pp.2687-2694 ISSN: 0968-0896 -
Benallegue N, Mazzaferro S, Alcaino C, Bermudez I, The Additional Ach Binding Site at the Alpha 4(+)/alpha 4(-) Interface of the (alpha 4 Beta 2)(2)alpha 4 Nicotinic Ach Receptor Contributes to Desensitization
British Journal of Pharmacology 170 (2013) pp.304-316 ISSN: 0007-1188 eISSN: 1476-5381 -
Mazzaferro S, Benallegue N, Carbone A, Gasparri F, Vijayan R, Biggin PC, Moroni M, Bermudez I, Additional Acetylcholine (ACh) Binding Site at alpha 4/alpha 4 Interface of (alpha 4 beta 2)(2)alpha 4 Nicotinic Receptor Influences Agonist Sensitivity
Journal of Biological Chemistry 286 (35) (2011) pp.31043-31054 ISSN: 0021-9258 eISSN: 1083-351X -
Lucero L, Bhakta M, Liu G, Wu J, Hauser TA, Bencherif M, Bermudez I, Whiteaker P, Lukas RJ, Tethered pentamers-Low sensitivity alpha 4 beta 2-nicotinic acetylcholine receptors
Biochemical Pharmacology 82 (8) (2011) pp.1025-1025 ISSN: 0006-2952 -
Singewald N, Sartori SB, Gaburro S, Schmuckermair C, Hetzenauer A, Rjabokon A, Franklin M, Bermudez I, Murck H, Shin JH, Lin L, Lubec G, Whittle N, Rodent magnesium-deficiency models for depression and their relationship to NMDA receptor/Nitric Oxide pathways
European Neuropsychopharmacology 20 (3) (2010) pp.366-366 ISSN: 0924-977X eISSN: 1873-7862 -
Franklin, M, Bermudez I, Mucha S, Singewald N, Gaburro S Murck H, Time defining effects of tryptophan depletion on hormone secretion and brain 5-HT2 binding in the rat.
Neuropsychopharmacology 20 (2010) pp.S357- ISSN: 0893-133X eISSN: 1740-634X -
Parsons A, Ingram J, Inglis J, Aveyard P, Johnstone E, Brown K, Franklin M, Bermudez I, A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to prevent weight gain on smoking cessation
Drug and Alcohol Dependence 102 (1-3) (2009) pp.116-122 ISSN: 0376-8716 -
Carbone A, Moroni M, Groot-Kormelink P, Bermudez-Diaz I, Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression
British Journal of Pharmacology 156 (6) (2009) pp.970-981 ISSN: 0007-1188 eISSN: 1476-5381 -
Moroni M, Vijayan R, Carbone A , Zwart R, Biggin P, Bermudez-Diaz I, Non-Agonist-Binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the α4β2 Nicotinic receptor: An α4–α4 interface is required for Zn2+ potentiation
The Journal of Neuroscience 28 (27) (2008) pp.6884-6894 ISSN: 0270-6474 eISSN: 1529-2401 -
Zwart R, Carbone A, Moroni M, Bermudez I, Mogg A, Folly E, Broad L, Williams A, Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors
Molecular Pharmacology 73 (6) (2008) pp.1838-1843 ISSN: 0026-895X eISSN: 1521-0111 -
Zwart R, Mogg A, Folly E, Broad LM, Carbone A, Moroni M, Williams A, Zhang D, Bermudez I, Sher E, Activation of recombinant and native alpha 4 beta 2 nicotinic acetylcholine receptors by sazetidine-A.
Biochemical Pharmacology 74 (2007) pp.SMA48- ISSN: 0006-2952 -
Iturriaga-Vasquez P, Perez EG, Slater EY, Bermudez I, Cassels BK, Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.
Bioorganic & Medicinal Chemistry 15 (2007) pp.3368-3372 ISSN: 0968-0896 -
Carbone AL, Moretti M, Zwart R, Gotti C Bermudez I., Functional and radioligand binding properties of alternate stoichiometries of human alpha 4 beta 2 nAChRs.
Biochemical Pharmacology 74 (2007) pp.SMA11-SMA12 ISSN: 0006-2952 -
Moroni M, Vijayan R, Biggin P, Carbone AL, Bermudez I, Identification of molecular determinants that mediate zinc effects on alternate stoichiometries of the human alpha 4 beta 2 nicotinic acetylcholine receptors.
Biochemical Pharmacology 74 (2007) pp.SMA11- ISSN: 0006-2952 -
Abin-Carriquiry JA, Kauppinen M, Barik J, Cassels BK, Iturriaga-Vasquez P, Bermudez I, Durand C, Dajas F, Wonnacott S, C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists.
European Journal of Pharmacology 536 (2006) pp.1-11 ISSN: 0014-2999 -
Cassels BK, Bermudez I, Dajas F, Abin-Carriquiry JA, Wonnacott S, From ligand design to therapeutic efficacy: The challenge for nicotinic receptor research
Drug Discovery Today 10 (2006) pp.1657-1665 ISSN: 1359-6446 -
Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I, α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry and sensitivity to long-term exposure to nicotine
Molecular Pharmacology 70 (2006) pp.755-768 ISSN: 0026-895X -
Exley R, Moroni M, Sasdelli F, Houlihan L, Lukas RJ, Sher E, Zwart R, Bermudez I, Cell surface expression and function of human α4β2 nicotinic acetylcholine receptors: Roles of relative subunit expression, α4 Subunit, phosphorylation, chaperone protein 14-3-3 and proten kinase
Journal of Neurochemistry 98 (2005) pp.870-875 ISSN: 0022-3042 -
SmuldersCJ, Zwart R, Bermudez I, van Kleef RG, Groot-Kormelink PJ, Vijberberg HP, Cholinergic drugs potentiate human nicotinic α4β2 acetylcholine receptors by a competitive mechanism
European Journal of Pharmacology 509 (2005) pp.97-108 ISSN: 0014-2999 -
Exley R, Iturriaga-Vásquez P, Lukas RJ, Sher E, Cassels BK, Bermudez I, Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
British Journal of Pharmacology 146 (2005) pp.15-24 ISSN: 0007-1188 eISSN: 1476-5381 -
Watson R, Jepson JEC, Bermudez I, Alexander S, Hart, Y, McKnight K, Roubertie A, Fecto F, Valmier J, Sattelle DB, Beeson D, Vincent A, Lang B, α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis
Neurology 65 (2005) pp.1802-1808 ISSN: 0028-3878 -
Watson R, Jiang L, Bermudez I, Houlihan L, Clover L, McKnight K, Cross JH, Hart IK, Roubertie A, Valmier J, Hart Y, Palace J, Beeson D, Vincent, Lang B, Absence of anitbodies to glutamate receptor type 3 (GLuR3) in Rasmussen encephalitis
Neurology 63 (2004) pp.43-50 ISSN: 0028-3878 -
Greenfield SA, Day T, Mann EO, Bermudez I, A novel peptide modulates α7 nicotinic receptor responses: implications for a possible trophic-toxic mechanism in the brain
Journal of Neurochemistry 90 (2004) pp.325-331 ISSN: 0022-3042 -
Maskell PD, Speder P, Newberry NR, Bermudez I, Inhibition of human α7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors
British Journal of Pharmacology 140 (2003) pp.1313-1319 ISSN: 0007-1188 eISSN: 1476-5381 -
Slater YE, Houlihan LM, Cassels BK, Lukas RJ, Bermudez I, Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors
European Journal of Pharmacology 450 (2002) pp.213-221 ISSN: 0014-2999 -
Slater YE, Houlihan LM, Maskell PD, Exley R, Bermudez I, Lukas RJ, Valdivia AC, Cassels BK, Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes
Neuropharmacology 44 (4) (2002) pp.503-515 ISSN: 0028-3908 -
Houlihan LM, Slater Y, Guerra DL, Peng JH, Kuo YP, Lukas RJ, Cassels BK, Bermudez I, Activity of Cytisine and Its Brominated Isosteres on Recombinant Human Alpha 7, Alpha 4 Beta 2 and Alpha 4 Beta 4 Nicotinic Acetylcholine Receptors
Journal of Neurochemistry 78 (2001) pp.1029-1043 ISSN: 0022-3042 eISSN: 1471-4159 -
Houlihan LM, Slater YE, Beadle DJ, Lukas RJ, Bermudez I, Effects of diltiazem on human nicotinic acetylcholine and GABA(A) receptors
Neuropharmacology 39 (2000) pp.2533-2542 ISSN: 0028-3908 -
Obosi LA, Hen R, Beadle DJ, Bermudez I, King LA, Mutational analysis of the mouse 5-HT7 receptor: importance of the third intracellular loop for receptor-G-protein interaction
FEBS Letters 412 (1997) pp.312-324 ISSN: 0014-5793 eISSN: 1873-3468 -
Aspinwall LS, Bermudez I, King LA, Wafford KA, The interactions of hexachlorocyclohexane isomers with human gamma- aminobutyric acid(A) receptors expressed in Xenopus oocytes
The Journal of Pharmacology and Experimental Therapeutics 282 (1997) pp.1557-1564 ISSN: 0022-3565 -
Obosi LA, Schuette DG, Europe-Finner GN, Beadle DJ, Hen R, King LA, Bermudez I, Functional characterization of the Drosophila 5-HTdro1 and 5-HTdro2b serotonin receptors in insect cells - activation of a G(Alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2b.
FEBS Letters 381 (4) (1996) pp.233-236 ISSN: 0014-5793 eISSN: 1873-3468
Other publications
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Franklin M, Hlavacova N, Babic S, Bermudez I, Jezova D, Pineal Melatonin in a Sub-chronic Tryptophan Depletion Female Rat Model of Treatment-resistant Depression
,
(2015) -
Bermudez Diaz I, Aldosterone increases earlier than corticosterone in new animal models of depression: Is this an early marker?
,
(2012) -
Barik J, Houlihan LM, Bermudez I, Slater Y, Tropisetron (ics 205-930) Interacts With Human Nicotinic Acetylcholine Receptors,
(2002)
Professional information
Conferences
Invited Talks:
- 2013 Neurotalk-2013, Xian, China
- 2014 3rd Welcome Trust Conference on Nicotinic Receptor Research, Cambridge, UK
- 2015 Membrane Signalling and Transport: Computation and Experiment, April, Oxford
- 2015 IST 18thWorld Congress 2015, September, Oxford
- 2016 Annual Meeting of the Chilena Pharmacological Society, December, Chiloe, Chile
- 2017 Workshop Instituto Butantan – United Kingdom, Science Dissemination, Animal Biology and Neuroscience, March, Sao Paulo, Brazil
- 2017 Nicotinic receptor research Conference, May, Crete,Greece
Further details
Press, publicity and reviews
- https://drive.google.com/file/d/0B6xzLVn3Y-3RYmVrT25PS3JaVG8/view?usp=sharing
Other publicity
- Meeting of the Chilean Pharmacological Society, Chiloe, Chile, December 2016
- Workshop Instituto Butantan – United Kingdom Science Dissemination, Animal Biology and Neuroscience, sao paulo, Brazil, March 2017