Dr Kate Lines

BSc(Hons), PhD

Emerging Leader Research Fellow

School of Biological and Medical Sciences

klines@brookes.ac.uk

Role

Kate is an Emerging Leaders Research Fellow running her own research group examining the role of epigenetic gene regulation in cancer. Prior to this Kate did an undergraduate degree in Biochemistry at the University of Liverpool, a PhD in Molecular Oncology at the Barts Cancer Institute, and gained >10 years postdoctoral research experience in endocrine cancer at the University of Oxford.

In addition to her research Kate is an Associate Editor for the journal Endocrine Oncology and on the Editorial board of Endocrinology Insights. Kate also has an active role in public engagement being the UK research Ambassador for the NET Cancer Foundation.

Research

Kate’s research is focused on understanding how regulation of gene expression via epigenetic mechanisms can lead to cancer, and using this information to develop new treatments. She has a particular interest in endocrine cancers, and more specifically neuroendocrine tumours (NETs). The 3 most commonly mutated genes in these tumours, MEN1, ATRX and DAXX all have roles in epigenetic mechanisms. Kate’s research therefore examines how these genes influence DNA methylation, histone organisation in chromosomes, and microRNA expression.

Kate also has an interest in improving scientific models for NET research and has therefore set up, and is leading the NET Models Consortium.

Projects

Projects as Principal Investigator, or Lead Academic if project is led by another Institution

Epigenetics of canine insulinomas: a good model of human disease? (01/01/2025 - 31/12/2025), funded by: Society for Endocrinology

Publications

Journal articles

English KA, Goldsworthy M, Willis B, Kooblall KG, Birla S, Selberherr A, Stevenson M, Shariq OA, Oberg AL, Wang T, Carmichael J, Mavrommatis K, Escoubet L, Thakker RV, Howles SA, Lines KE, Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms
International Journal of Cancer [online first] (2024) ISSN: 0020-7136 eISSN: 1097-0215 Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms Open Access version on RADAR
Ear PH, Marinoni I, Dayton T, Guenter R, Quelle D, Battistella A, Buishand FO, Chittaranjan S, Yi-Cheih ND, Marques I, Pellegata N, Sadowski SM, Tirosh A, April-Monn S, Aurilia C, Jaskula-Sztul R, Baena Moreno MJ, Donati S, English KA, Hernandez Llorens MA., Hodgetts H, Marini F, Martins M, Palmini G, Soldevilla B, Schrader J, Thakker RV, Lines KE, NET models meeting 2024: the current state of neuroendocrine tumour research models and our future aspirations
Endocrine Oncology [online first] (2024) ISSN: 2634-4793 eISSN: 2634-4793 NET models meeting 2024: the current state of neuroendocrine tumour research models and our future aspirations Open Access version on RADAR
Kooblall KG, Stevenson M, Heilig R, Stewart M, Wright B, Lockstone H, Buck D, Fischer R, Wells S, Lines KE, Teboul L, Hennekam RC, Thakker RV, Identification of cellular retinoic acid binding protein 2 (CRABP2) as downstream target of nuclear factor I/X (NFIX): implications for skeletal dysplasia syndromes
JBMR Plus 8 (7) (2024) ISSN: 2473-4039 eISSN: 2473-4039
Zecchin D, Knöpfel N, Gluck AK, Stevenson M, Sauvadet A, Polubothu S, Barberan-Martin S, Michailidis F, Bryant D, Inoue A, Lines KE, Hannan FM, Semple RK, Thakker RV, Kinsler VA, GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics
Journal of Investigative Dermatology 144 (4) (2024) pp.811-819 ISSN: 0022-202X eISSN: 1523-1747
English KA, Lines KE, Thakker RV, Genetics of hereditary forms of primary hyperparathyroidism
Hormones 23 (2023) pp.3-14 ISSN: 1109-3099 eISSN: 2520-8721
Pagnamenta AT, Camps C, Giacopuzzi E, Taylor JM., Hashim M, Calpena E, Kaisaki PJ, Hashimoto A, Yu J, Sanders E, Schwessinger R, Hughes JR, Lunter G, Dreau H, Ferla M, Lange L, Kesim Y, Ragoussis V, Vavoulis DV, Allroggen H, Ansorge O, Babbs C, Banka S, Baños-Piñero B, Beeson D, Ben-Ami T, Bennett DL, Bento C, Blair E, Brasch-Andersen C, Bull KR, Cario H, Cilliers D, Conti V, Davies EG, Dhalla F, Dacal BD, Dong Y, Dunford JE, Guerrini R, Harris AL, Hartley J, Hollander G, Javaid K, Kane M, Kelly D, Kelly D, Knight SJL, Kreins AY, Kvikstad EM, Langman CB, Lester T, Lines KE, Lord SR, Lu X, Mansour S, Manzur A, Maroofian R, Marsden B, Mason J, McGowan SJ, Mei D, Mlcochova H, Murakami Y, Németh AH, Okoli S, Ormondroyd E, Ousager LB, Palace J, Patel SY, Pentony MM, Pugh C, Rad A, Ramesh A, Riva SG, Roberts I, Roy N, Salminen O, Schilling KD, Scott C, Sen A, Smith C, Stevenson M, Thakker RV, Twigg SRF, Uhlig HH, van Wijk R, Vona B, Wall S, Wang J, Watkins H, Zak J, Schuh AH, Kini U, Wilkie AOM, Popitsch N, Taylor JC, Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases
Genome Medicine 15 (2023) eISSN: 1756-994X
Srivastava K, Lines KE, Jach D, Crnogorac-Jurcevic T, S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer
Oncogene 42 (2023) pp.3422-3434 ISSN: 0950-9232 eISSN: 1476-5594
English Katherine A, Thakker Rajesh V, Lines Kate E, The role of DNA methylation in human pancreatic neuroendocrine tumours
Endocrine Oncology 3 (1) (2023) eISSN: 2634-4793
Kooblall KG, Stevenson M, Stewart M, Harris L, Zalucki O, Dewhurst H, Butterfield N, Leng H, Hough TA, Ma D, Siow B, Potter P, Cox RD, Brown SDM, Horwood N, Wright B, Lockstone H, Buck D, Vincent TL, Hannan FM, Bassett JHD, Williams GR, Lines KE, Piper M, Wells S, Teboul L, Hennekam RC, Thakker RV, A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (NFIX) Gene Has Phenotypic Features of Marshall‐Smith Syndrome
JBMR Plus 7 (6) (2023) ISSN: 2473-4039 eISSN: 2473-4039 A Mouse Model with a Frameshift Mutation in the Nuclear Factor I/X (NFIX) Gene Has Phenotypic Features of Marshall‐Smith Syndrome Open Access version on RADAR
Sedlack AJH, Saleh-Anaraki K, Kumar S, Ear PH, Lines KE, Roper N, Pacak K, Bergsland E, Quelle DE, Howe JR, Pommier Y, del Rivero J, Preclinical Models of Neuroendocrine Neoplasia
Cancers 14 (22) (2022) ISSN: 2072-6694 eISSN: 2072-6694
Kooblall KG, Stokes VJ, Shariq OA, English KA, Stevenson M, Broxholme J, Wright B, Lockstone HE, Buck D, Grozinsky-Glasberg S, Yates CJ, Thakker RV, Lines KE, miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2
Endocrine-Related Cancer 29 (10) (2022) pp.557-568 ISSN: 1351-0088 eISSN: 1479-6821
Stevenson M, Pagnamenta AT, Mack HG, Savige J, Giacopuzzi E, Lines KE, Taylor JC, Thakker RV, The Bartter-Gitelman Spectrum: 50-Year Follow-up With Revision of Diagnosis After Whole-Genome Sequencing
Journal of the Endocrine Society 6 (7) (2022) eISSN: 2472-1972
Shariq OA., Lines KE, English KA, Jafar-Mohammadi B, Prentice P, Casey R, Challis BG, Selberherr A, Boon H, Cranston T, Ryan FJ, Mihai R, Healy U, Kurzawinski T, Dattani MT, Bancos I, Dy BM, Lyden ML, Young WF, McKenzie TJ, Richards D, Thakker RV, Multiple endocrine neoplasia type 1 in children and adolescents: Clinical features and treatment outcomes
Surgery 171 (1) (2022) pp.77-87 ISSN: 0039-6060 eISSN: 1532-7361
Lines KE, Stevenson M, Mihai R, Grigorieva IV, Shariq OA, Gaynor KU, Jeyabalan J, Javid M, Thakker RV, Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells
Endocrine Oncology 1 (1) (2021) pp.23-32 eISSN: 2634-4793
Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L, Wu X, O’Toole S, Goodchild E, Marker A, Senanayake R, Garg S, Åkerström T, Backman S, Jordan S, Polubothu S, Berney DM, Gluck A, Lines KE, Thakker RV, Tuthill A, Joyce C, Kaski JP, Karet FFE, Metherell LA, Teo AED, Gurnell M, Parvanta L, Drake WM, Wozniak E, Klinzing D, Kuan JL, Tiang Z, Gomez SCE, Hellman P, Foo RSY, Mein CA, Kinsler VA, Björklund P, Storr HL, Zennaro M-C, Brown MJ, Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause
Nature Genetics 53 (2021) pp.1360-1372 ISSN: 1061-4036 eISSN: 1546-1718
Lines KE, Gluck AK, Thongjuea S, Bountra C, Thakker RV, Gorvin CM, The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines
Journal of Molecular Endocrinology 67 (3) (2021) pp.83-94 ISSN: 0952-5041 eISSN: 1479-6813
Sastre A, Valentino K, Hannan FM, Lines KE, Gluck AK, Stevenson M, Ryalls M, Gorrigan RJ, Pullen D, Buck J, Sankaranarayanan S, Allgrove J, Thakker RV, Gevers EF, PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1
New England Journal of Medicine 385 (2) (2021) pp.189-191 ISSN: 0028-4793 eISSN: 1533-4406
Brandi ML, Agarwal SK, Perrier ND, Lines KE, Valk GD, Thakker RV, Multiple Endocrine Neoplasia Type 1: Latest Insights
Endocrine Reviews 42 (2) (2020) pp.133-170 ISSN: 0163-769X eISSN: 1945-7189
Lines KE, Nachtigall LB, Dichtel LE, Cranston T, Boon H, Zhang X, Kooblall KG, Stevenson M, Thakker RV, Multiple Endocrine Neoplasia Type 1 (MEN1) Phenocopy Due to a Cell Cycle Division 73 (<i>CDC73</i>) Variant
Journal of the Endocrine Society 4 (11) (2020) eISSN: 2472-1972
Kooblall KG, Boon H, Cranston T, Stevenson M, Pagnamenta AT, Rogers A, Grozinsky-Glasberg S, Richardson T, Flanagan DEH, Taylor JC, Lines KE, Thakker RV, Multiple Endocrine Neoplasia Type 1 (MEN1) 5′UTR Deletion, in MEN1 Family, Decreases Menin Expression
Journal of Bone and Mineral Research 36 (1) (2020) pp.100-109 ISSN: 0884-0431 eISSN: 1523-4681
Stevenson M, Pagnamenta AT., Reichart S, Philpott C, Lines KE, Gorvin CM, Lhotta K, Taylor JC, Thakker RV, Whole genome sequence analysis identifies a PAX2 mutation to establish a correct diagnosis for a syndromic form of hyperuricemia
The American Journal of Medical Genetics - Part A 182 (11) (2020) pp.2521-2528 ISSN: 1552-4825 eISSN: 1552-4833
Nachtigall LB, Guarda FJ, Lines KE, Ghajar A, Dichtel L, Mumbach G, Zhao W, Zhang X, Tritos NA, Swearingen B, Miller KK, Thakker RV, Clinical MEN-1 Among a Large Cohort of Patients With Acromegaly
The Journal of Clinical Endocrinology & Metabolism 105 (2020) ISSN: 0021-972X eISSN: 1945-7197
Lines KE, Filippakopoulos P, Stevenson M, Müller S, Lockstone H E, Wright B, Knapp S, Buck D, Bountra C, Thakker RV, Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells
Endocrine-Related Cancer 27 (2020) ISSN: 1351-0088 eISSN: 1479-6821
Lines KE, Javid M, Reed AAC, Walls GV, Stevenson M, Simon M, Kooblall KG, Piret SE, Christie PT, Newey PJ, Mallon A-M, Thakker RV, Genetic background influences tumour development in heterozygous Men1 knockout mice
Endocrine Connections 9 (2020) ISSN: 2049-3614 eISSN: 2049-3614
Pieterman CRC, Sadowski SM, Maxwell JE, Katz MHG, Lines KE, Heaphy CM, Tirosh A, Blau JE, Perrier ND, Lewis MA, Metzcar JP, Halperin DM, Thakker RV, Valk GD, HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: MEN1-related pancreatic NETs: identification of unmet clinical needs and future directives
Endocrine-Related Cancer 27 (2020) ISSN: 1351-0088 eISSN: 1479-6821
Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV, Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs)
Endocrine-Related Cancer 27 (9) (2020) ISSN: 1351-0088 eISSN: 1479-6821
Gorvin CM, Stokes VJ, Boon H, Cranston T, Glück AK, Bahl S, Homfray T, Aung T, Shine B, Lines KE, Hannan FM, Thakker RV, Activating Mutations of the G-protein Subunit α 11 Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2
The Journal of Clinical Endocrinology & Metabolism 105 (2019) ISSN: 0021-972X eISSN: 1945-7197
Lines KE, Newey PJ, Yates CJ, Stevenson M, Dyar R, Walls GV, Bowl MR, Thakker RV, miR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs
Journal of Endocrinology 240 (2019) ISSN: 0022-0795 eISSN: 1479-6805
Schorr M, Zhang X, Zhao W, Abedi P, Lines KE, Te H-WE, Swearingen B, Klibanski A, Miller KK, Thakker RV, Nachtigall LB, Two Synchronous Pituitary Adenomas Causing Cushing Disease and Acromegaly
AACE Clinical Case Reports 5 (2019) ISSN: 2376-0605
Gorvin CM, Newey PJ, Rogers A, Stokes V, Neville MJ, Lines KE, Ntali G, Lees P, Morrison PJ, Singhellakis PN, Malandrinou FCh, Karavitaki N, Grossman AB, Karpe F, Thakker RV, Association of prolactin receptor (<i>PRLR</i>) variants with prolactinomas
Human Molecular Genetics 28 (2018) ISSN: 0964-6906 eISSN: 1460-2083
Frost M, Lines KE, Thakker RV, Current and emerging therapies for PNETs in patients with or without MEN1
Nature Reviews Endocrinology 14 (2018) ISSN: 1759-5029 eISSN: 1759-5037
Stevenson M, Lines KE, Thakker RV, Molecular genetic studies of pancreatic neuroendocrine tumors reveal new therapeutic approaches
Endocrinology and Metabolism Clinics of North America 47 (2018) ISSN: 0889-8529
Lines KE, Stevenson M, Filippakopoulos P, Müller S, Lockstone H E, Wright B, Grozinsky-Glasberg S, Grossman AB, Knapp S, Buck D, Bountra C, Thakker RV, Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors
Oncogenesis 6 (2017) eISSN: 2157-9024
Walls GV, Stevenson M, Lines KE, Newey PJ, Reed AAC, Bowl MR, Jeyabalan J, Harding B, Bradley KJ, Manek S, Chen J, Wang P, Williams BO, Teh BT, Thakker RV, Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome
Oncogene 36 (2017) ISSN: 0950-9232 eISSN: 1476-5594
Lines KE, Vas Nunes RP, Frost M, Yates CJ, Stevenson M, Thakker RV, A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control
Endocrine Connections 6 (2017) ISSN: 2049-3614 eISSN: 2049-3614
Walls GV, Stevenson M, Soukup BS, Lines KE, Grossman AB, Schmid HA, Thakker RV, Pasireotide Therapy of Multiple Endocrine Neoplasia Type 1–Associated Neuroendocrine Tumors in Female Mice Deleted for an Men1 Allele Improves Survival and Reduces Tumor Progression
Endocrinology 157 (2016) ISSN: 0013-7227 eISSN: 1945-7170
Lines KE, Stevenson M, Thakker RV, Animal models of pituitary neoplasia
Molecular and Cellular Endocrinology 421 (2016) ISSN: 0303-7207
Fetahu IS, Tennakoon S, Lines KE, Gröschel C, Aggarwal A, Mesteri I, Baumgartner-Parzer S, Mader RM, Thakker RV, Kállay E, miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors
International Journal of Cancer 138 (2015) ISSN: 0020-7136 eISSN: 1097-0215
Yates CJ, Lines KE, Thakker RV, Molecular genetic advances in pituitary tumor development
Expert Review of Endocrinology & Metabolism 10 (2014) ISSN: 1744-6651 eISSN: 1744-8417
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR, Crnogorac-Jurcevic T, S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
Clinical and Experimental Metastasis 30 (2012) ISSN: 0262-0898 eISSN: 1573-7276
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T, S100P-Binding Protein, S100PBP, Mediates Adhesion through Regulation of Cathepsin Z in Pancreatic Cancer Cells
The American Journal of Pathology 180 (2012) ISSN: 0002-9440 eISSN: 1525-2191