Dr Mark Poolman
BSc, PhD
Senior Research Fellow in Systems Biology
School of Biological and Medical Sciences
Role
Dr Mark Poolman is Senior Research Fellow in Systems Biology in the School of Biological and Medical Sciences.
Research
Research group membership
- Cell systems modelling.
Projects as Principal Investigator, or Lead Academic if project is led by another Institution
- BBSRC Institute Strategic Programme: Microbes and Food Safety Partner Grant (led by Quadram Institute) (01/04/2023 - 31/03/2028), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £661,889
- Innovative approaches to identification of metabolic Targets for antimicrobials (led by Kobenhavns Universitet) (01/03/2021 - 30/11/2025), funded by: European Commission, funding amount received by Brookes: £218,058
- Carbon Recycling: Converting Waste derived GHG into... (CCnet) - led by University of Nottingham (01/01/2019 - 31/03/2025), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £24,773
Publications
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Journal articles
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Norman ROJ, Millat T, Schatsschneider S, Henstra AM, Breitkopf R, Oander B, Annan FJ, Piatek P, Hartman HB, Poolman MG, Fell DA, Winzer K, Minton NP, Hodgman C., A genome-scale model of Clostridium autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide.
Engineering Biology 3 (2) (2019) pp.32-40 ISSN: 2398-6182 A genome-scale model of Clostridium autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide. Open Access version on RADAR -
Huma B, Kundu S, Poolman MG; Kruger N, Fell DA, Stoichiometric analysis of the energetics and metabolic impact of photorespiration in C3 plants
The Plant Journal 96 (6) (2018) pp.1228-1241 ISSN: 0960-7412 eISSN: 1365-313X Stoichiometric analysis of the energetics and metabolic impact of photorespiration in C3 plants Open Access version on RADAR -
Pfau T, Christian N, Masakapalli S, Sweetlove L, Poolman M, Ebenhöh O, The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling
Scientific Reports 8 (2018) ISSN: 2045-2322 The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling Open Access version on RADAR -
Fatma Z, Hartman H, Poolman MG, Fell DA, Srivastava S, Shakeela T, Yazdani SS, Model-assisted metabolic engineering of Escherichia coli for long chain alkane and alcohol production
Metabolic Engineering 48 (2018) pp.1-12 ISSN: 1096-7176 eISSN: 1096-7184 Model-assisted metabolic engineering of Escherichia coli for long chain alkane and alcohol production Open Access version on RADAR -
Villanova V, Fortunato A, Singh D, Dal Bo D, Davide Conte M, Obata T, Johuet J, Fernie A, Maréchal E Falciatore A, Pagliardini J, Le Monnier A, Poolman M, Curien G, Petroutsos D, Finazzi G, Investigating mixotrophic metabolism in the model diatom Phaeodactylum tricornutum
Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1728) (2017) ISSN: 0962-8436 Investigating mixotrophic metabolism in the model diatom Phaeodactylum tricornutum Open Access version on RADAR -
Matuszyńska A , Moejes F, Adhikari K, Bassi R, Cariti F, Cogne G, Dikaios I, Falciatore A, Finazzi G, Flori S, Goldschmidt-Clermont M, Magni S, Maguire J, Le Monnier A, Müller K , Poolman M, Singh D, Spelberg S, Stella G, Succurro A, Taddei L, Urbain B, Villanova V, Zabke C, Ebenhöh O, A systems-wide understanding of photosynthetic acclimation in algae and higher plants
Journal of Experimental Botany 68 (11) (2017) pp.2667-2681 ISSN: 0022-0957 A systems-wide understanding of photosynthetic acclimation in algae and higher plants Open Access version on RADAR -
Pentjuss A, Stalidzans E, Liepins J, Kokina A, Martynova J, Zikmanis P, Mozga I, Scherbaka R, Hartman H, Poolman M, Fell D, Vigants A, Model based biotechnological potential analysis of Kluyveromyces marxianus central metabolism
Journal of Industrial Microbiology and Biotechnology 44 (8) (2017) pp.1177-1190 ISSN: 1367-5435 eISSN: 1476-5535 Model based biotechnological potential analysis of Kluyveromyces marxianus central metabolism Open Access version on RADAR -
Ahmad A, Hartman H , Krishnakumar S, Fell D, Poolman M, Srivastava S, A genome scale model of Geobacillus thermoglucosidasius (C56-YS93) reveals its biotechnological potential on rice straw hydrolysate
Journal of Biotechnology 251 (2017) pp.30-37 ISSN: 0168-1656 A genome scale model of Geobacillus thermoglucosidasius (C56-YS93) reveals its biotechnological potential on rice straw hydrolysate Open Access version on RADAR -
Singh D, Carlson R, Fell D, Poolman M, Modelling metabolism of the diatom Phaeodactylum tricornutum
Biochemical Society Transactions 43 (6) (2015) pp.1182-1186 ISSN: 0300-5127 -
Hartman HB, Fell DA, Rossell S, Jensen PR, Woodward MJ, Thorndahl L, Jelsbak L, Olsen JE, Raghunathan A, Daefler S, Poolman MG, Identification of potential drug targets in Salmonella enterica sv. Typhimurium using metabolic modelling and experimental validation
Microbiology 160 (2014) pp.1252-1266 ISSN: 1350-0872 eISSN: 1465-2080 -
Jelsbak L, Hartman H, Schroll C, Rosenkrantz JT, Lemire S, Wallrodt I, Thomsen LE, Poolman M, Kilstrup M, Jensen PR, Olsen JE, Identification of Metabolic Pathways Essential for Fitness of Salmonella Typhimurium In Vivo
PLoS ONE 9 (7) (2014) ISSN: 1932-6203 Identification of Metabolic Pathways Essential for Fitness of Salmonella Typhimurium In Vivo Open Access version on RADAR -
Poolman MG, Kundu S, Shaw R, Fell DA, Metabolic trade-offs between biomass synthesis and photosynthate export at different light intensities in a genome-scale metabolic model of rice
Frontiers in Plant Science 5 (2014) ISSN: 1664-462X eISSN: 1664-462X -
Cheung CYM, Williams TCR, Poolman MG, Fell DA, Ratcliffe RG, Sweetlove LJ, A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions
The Plant Journal 75 (6) (2013) pp.1050-1061 ISSN: 0960-7412 -
Jacobs L, Bewicke-Copley F, Poolman M, Pink R, Mulcahy L, Baker I, Beaman E, Brooks T, Caley D, Cowling W, Currie J, Horsburgh J, Kenehan L, Keyes E, Leite D, Massa D , McDermott-Rouse A, Samuel P, Wood H, Kadhim M, Carter D, Meta-analysis using a novel database, miRStress, reveals miRNAs that are frequently associated with the radiation and hypoxia stress-responses
PLoS ONE 8 (11) (2013) pp.e80844- ISSN: 1932-6203 eISSN: 1932-6203 Meta-analysis using a novel database, miRStress, reveals miRNAs that are frequently associated with the radiation and hypoxia stress-responses Open Access version on RADAR -
Fell D, Poolman M G, Kundu S, Shaw R, Responses to Light Intensity in a Genome-Scale Model of Rice Metabolism
Plant Physiology 162 (2) (2013) pp.1060-1072 ISSN: 0032-0889 eISSN: 1532-2548 -
Poolman MG, Kundu S, Shaw R, Fell DA, Responses to Light Intensity in a Genome–Scale Model of Rice Metabolism
Plant Physiology 162 (2) (2013) pp.1060-1072 ISSN: 0032-0889 eISSN: 1532-2548 -
Williams TCR, Poolman MG, Howden AJM, Schwarzlander M, Fell DA, Ratcliffe RG, Sweetlove LJ, A genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions.
Plant Physiology 154 (1) (2010) pp.311-323 ISSN: 0032-0889 eISSN: 1532-2548 -
Fell D, Poolman M, Gevorgyan A, Building and analysing genome-scale metabolic models
Biochemical Society Transactions 38 (5) (2010) pp.1197-1201 ISSN: 0300-5127 eISSN: 1470-8752 -
Poolman MG, Miguet L, Sweetlove LJ, Fell DA, A Genome-Scale Metabolic Model of Arabidopsis and Some of its Properties.
Plant Physiology 151 (3) (2009) pp.1570-1581 ISSN: 0032-0889 eISSN: 1532-2548 -
Chase JR, Poolman MG, Fell DA, Contribution of NADH Increases to Ethanol's Inhibition of Retinol Oxidation by Human ADH Isoforms
Alcoholism: Clinical and Experimental Research 33 (4) (2009) pp.571-580 ISSN: 0145-6008 eISSN: 1530-0277 -
Gevorgyan A, Poolman MG, Fell D, Detection of stoichiometric inconsistencies in biomolecular models
Bioinformatics 24 (19) (2008) pp.2245-2251 ISSN: 1367-4803 -
Poolman MG, Sebu C, Pidcock MK, Fell DA, Modular decomposition of metabolic systems via null-space analysis
Journal of Theoretical Biology 249 (4) (2007) pp.691-705 ISSN: 0022-5193 -
Fell D, Poolman M, Sebu C, Pidcock M, Modular decomposition of metabolic systems via null space analysis
Journal of Theoretical Biology 249 (4) (2007) pp.691-705 ISSN: 0022-5193 -
Poolman MG, Bonde BK, Gevorgyan A, Patel HH, Fell DA, Challenges to be faced in the reconstruction of metabolic networks from public databases
Systems Biology 153 (5) (2006) pp.379-384 ISSN: 1741-2471 eISSN: 1741-248X -
Poolman MG, Venkatesh KV, Pidcock MK, Fell DA, A Method for the Determination of Flux in Elementary Modes, and its Application to Lactobacillus rhamnosus
Biotechnology and Bioengineering 88 (2004) pp.601-612 ISSN: 0006-3592 -
Poolman MG, Assmus HE, Fell DA, Applications of Metabolic Modelling to Plant Metabolism
Journal of Experimental Botany 55 (2004) pp.1177-1186 ISSN: 0022-0957 eISSN: 1460-2431 -
Vogt AM, Nef H, Schaper J, Poolman M, Fell DA, Kubler W, Elsasser A, Metabolic Control Analysis of Anaerobic Glycolysis in Human Hibernating Myocardium Replaces Traditional Concepts of Flux Control
FEBS Letters 517 (2002) pp.245-250 ISSN: 0014-5793 eISSN: 1873-3468 -
Vogt AM, Poolman M, Ackermann C, Yildiz M, Schoels W, Fell DA, Kubler W, Regulation of Glycolytic Flux in Ischemic Preconditioning - a Study Employing Metabolic Control Analysis
Journal of Biological Chemistry 277 (2002) pp.24411-24419 ISSN: 0021-9258 eISSN: 1083-351X -
Poolman MG, Fell DA, Thomas S, Modelling Photosynthesis and Its Control
Journal of Experimental Botany 51 (1) (2000) pp.319-328 ISSN: 0022-0957 eISSN: 1460-2431 -
Thomas S, Moniz-Barrito JP, Fell DA, Woods JH, Poolman MG, Flux Control in Ecosystems
Trends in Ecology & Evolution 10 (1995) pp.245-245 ISSN: 0169-5347 eISSN: 1872-8383