Teaching and supervision
I am the Subject Co-ordinator for BSc Biomedical Science, and the Module Leader for
- Professional and Experiemental Skills
- Biochemistry of Cell Function
|Gabrielle Mastrolonardo||Investigating the functional role of NFXL1 in the developing brain and how it relates to speech and language development||Active|
We are made up of cells that differ dramatically in their size, shape, function, longevity and ability to keep dividing even though, with few exceptions, every cell contains the same genome. The great diversity of cells observed in an adult human is a consequence of the different cell types expressing different profiles of genes. Failure of correct gene regulation during foetal development usually results in death or severe congenital defects, and in adult life leads to disease including cancer.
My research group uses a combination of Drosophila genetics, molecular biology, biochemistry and immunohistochemistry to study the mechanisms that transcription factors use to regulate gene expression during animal development.
Bar-Cohen S, Martínez Quiles ML, Baskin A, Dawud R, Jennings BH, Paroush Z, 'Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase'
Development 150 (11) (2023)
ISSN: 0950-1991 eISSN: 1477-9129Abstract Published here Open Access on RADAR
Roehrig, A.E., Klupsch, K., Oses-Prieto, J.A., Chaib, S., Henderson, S., Emmett, W., Young, L.C., Surinova, S., Blees, A., Pfeiffer, A., Tijani, M., Brunk, F., Hartig, N., Muñoz-Alegre, M., Hergovich, A., Jennings, B.H., Burlingame, A.L., Rodriguez-Viciana, P., , 'Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex'
PLoS ONE 16 (8) (2021)
ISSN: 1932-6203 eISSN: 1932-6203Abstract Published here Open Access on RADAR
Kaul AK, Schuster EF, Jennings BH, 'Recent insights into Groucho co-repressor recruitment and function'
Transcription 6 (1) (2015) pp.7-11
ISSN: 2154-1264 eISSN: 2154-1272Abstract Published here Open Access on RADAR
Kaul A, Schuster E, Jennings BH, 'The Groucho Co-repressor Is Primarily Recruited to Local Target Sites in Active Chromatin to Attenuate Transcription'
PLoS Genetics 10 (8) (2014)
ISSN: 1553-7390Abstract Published here
Harvey R, Schuster E, Jennings BH, 'Pleiohomeotic Interacts with the Core Transcription Elongation Factor Spt5 to Regulate Gene Expression in Drosophila'
PLoS ONE 8 (7) (2013)
ISSN: 1932-6203Abstract Published here
Jennings BH, 'Pausing for thought: Disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis'
BioEssays 35 (6) (2013) pp.553-560
ISSN: 0265-9247Abstract Published here
Jennings BH, 'Drosophila - a versatile model in biology & medicine'
Materials Today 14 (2011) pp.190-195
Joly P, Jennings BH, Jayasinghe SN, 'Development and fertility studies on post-bio-electrosprayed Drosophila melanogaster embryos'
Biomicrofluidics 3 (2009)
ISSN: 1932-1058Abstract Published here
Jennings BH, Wainwright SM, Ish-Horowicz D, 'Differential in vivo requirements for oligomerization during Groucho-mediated repression'
EMBO Reports 9 (2008) pp.76-83
ISSN: 1469-221X eISSN: 1469-3178Abstract Published here
Jennings BH, Ish-Horowicz D, 'The Groucho/TLE/Grg family of transcriptional co-repressors'
Genome Biology 9 (2008)
ISSN: 1474-760XAbstract Published here
Jennings BH, Pickles LM, Wainwright SM, Roe SM, Pearl LH, Ish-Horowicz D, 'Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor'
Molecular Cell 22 (2006) pp.645-655
ISSN: 1097-2765 eISSN: 1097-4164Abstract Published here
Jennings BH, Shah S, Yamaguchi Y, Seki M, Phillips RG, Handa H, Ish-Horowicz D, 'Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila'
Current Biology 14 (2004) pp.1680-1684
ISSN: 0960-9822Abstract Published here
Jennings BH, Tyler DM, Bray SJ, 'Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins'
Molecular and Cellular Biology 19 (1999) pp.4600-4610
Memberships of professional bodies
- Academic Editor PLOS ONE
- British Society of Developmental Biology
- British Society of Cell Biology
- The Genetics Society