Professor Linda King

BSc, DPhil, FRSB

Pro Vice-Chancellor - Research and Global Partnerships

Department of Biological and Medical Sciences

Linda King

Role

Professor Linda King is Pro Vice-Chancellor for Research and Global Partnerships.

Linda joined Oxford Brookes in 1986 as a Lecturer in Virology and was promoted to Professor in 1998. She was Dean of the School of Life Sciences for eight years until she became Associate Dean for Research and Knowledge Exchange for the Faculty of Health and Life Sciences.

Linda completed her doctorate in molecular virology at Oxford University in 1985. Her research has focused on understanding the biology of insect viruses and on their exploitation in agriculture, medicine and biotechnology.

She is co-founding director of a joint Brookes and Natural Environment Research Council spin-out biotech company.

Having published more than 100 papers in peer-reviewed journals, reviews and book chapters, Linda has also spoken at numerous national and international meetings, including The American Society for Virology, The Society for Invertebrate Pathology, Peptalk, Global Protein Summit and Baculovirus Technology.

Research

Following the completion of my doctorate in molecular virology at Oxford University in 1985, my research has focused on various aspects of insect virology with particular emphasis on baculovirus expression systems. I have published more than 90 papers in peer-reviewed journals, reviews and book chapters, and until recently was Insect Virus Editor for The Journal of General Virology. I have spoken at numerous national and international meetings, including The American Society for Virology, The Society for Invertebrate Pathology, Peptalk, Global Protein Summit and Baculovirus Technology.

I also played an integral role in the establishment of Oxford Expression Technologies (OET), trading under Oxford Brookes Enterprises Ltd, in 1997 and continue to work as Director and Chair of SAB. 

The biology and replication of insect baculoviruses in cultured insect cells and in larvae, with a focus on the role of non-essential genes encoding proteins such as P10. chitinase and cathepsin, and the trafficking of virus proteins and particles through insect cells using a range of bioimaging techniques. We are also interested in the exploitation of baculoviruses as gene expression vectors that has led to patenting of a new platform technology ‘flashBAC’ for the production of recombinant viruses and the formation of spin-off company Oxford Expression Technologies Ltd.

Groups

Projects as Principal Investigator, or Lead Academic if project is led by another Institution

  • COVID-19: a rapidly scalable SARS-CoV-2 vaccine platform based on recombinant spike protein manufactured in insect cells using flashBAC to maximise yield and quality (led by OET) (11/05/2020 - 31/12/2022), funded by: Technology Strategy Board (Innovate UK), funding amount received by Brookes: £46,431
  • Investigating the role of extracellular vesicles in baculovirus replication (01/10/2019 - 31/03/2023), funded by: Oxford Expression Technologies Ltd, funding amount received by Brookes: £41,879
  • Gene regulation in baculovirus-infected insect cells: application in the development of a budded virus-free expression system for the production of VLP-based vaccines (17/09/2018 - 16/09/2022), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £96,562

Publications

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Professional information

Memberships of professional bodies

  • Society for General Microbiology
  • Society for Invertebrate Pathology
  • Fellow of the Society of Biology