Dr Sebastian Kittelmann

Research Fellow

School of Biological and Medical Sciences

skittelmann@brookes.ac.uk

Teaching and supervision

Courses

Medical Genetics and Genomics (MSc, PGDip, PGCert)

Modules taught

Interrogating Genomes (BIOL5002)
Molecular Biology (BIOL5014)
Data Carpentry (BIOL5017)
Project (BIOS6010)
The Practising Scientist (BIOL4004)
Genome Science (BIOS7002)

CFG Workshop : Computing Skills for Biologists

Research

I am interested in how genes are regulated, and especially how transcription of the same genes is controlled in different tissues or developmental time points. I use fruit flies (Drosophila) as a model system and the methodology of my research includes next generation sequencing, molecular biology, and genetics.

Centres and institutes

Centre for Functional Genomics (CfG)

Groups

Regulation of Gene Expression

Projects as Principal Investigator, or Lead Academic if project is led by another Institution

Evolving New Neural Circuits: Insect Lineages As ‘evolvable Modules (led by KCL) (01/05/2022 - 30/04/2026), funded by: Leverhulme Trust, funding amount received by Brookes: £0

Projects as Co-investigator

TFTag: A novel library of tagged transcription factors in Drosophila(01/12/2022 - 30/11/2027), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £1,144,262, funded by: Biotechnology & Biological Sciences Research Council (BBSRC)

Publications

Journal articles

Buffry A, Kittelmann S, McGregor A, Characterisation of the role and regulation of <i>Ultrabithorax</i> in sculpting fine-scale leg morphology.
Frontiers in Cell and Developmental Biology 11 (2023) ISSN: 2296-634X eISSN: 2296-634X Characterisation of the role and regulation of <i>Ultrabithorax</i> in sculpting fine-scale leg morphology. Open Access version on RADAR
Kittelmann S, Preger-Ben Noon E, McGregor AP, Frankel N, A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila
Current Opinion in Genetics & Development 69 (2021) pp.21-27 ISSN: 0959-437X A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila Open Access version on RADAR
Herndon N, Shelton J, Gerischer L, Ioannidis P, Ninova M, Dönitz J, Waterhouse RM, Liang C, Damm C, Siemanowski J, Kitzmann P, Ulrich J, Dippel S, Oberhofer G, Hu Y, Schwirz J, Schacht M, Lehmann S, Montino A, Posnien N, Gurska D, Horn T, Seibert J, Vargas Jentzsch IM, Panfilio KA, Li J, Wimmer EA, Stappert D, Roth S, Schröder R, Park Y, Schoppmeier M, Chung H, Klingler M, Kittelmann S, Friedrich M, Chen R, Altincicek B, Vilcinskas A, Zdobnov E, Griffiths-Jones S, Ronshaugen M, Stanke M, Brown SJ, Bucher G, Enhanced genome assembly and a new official gene set for Tribolium castaneum
BMC Genomics 21 (2020) ISSN: 1471-2164 Enhanced genome assembly and a new official gene set for Tribolium castaneum Open Access version on RADAR
Kittelmann S, McGregor AP, Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression
Genes 10 (4) (2019) ISSN: 2073-4425 eISSN: 2073-4425 Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression Open Access version on RADAR
Kittelmann S, Buffry AD, Franke FA, Almudi I, Yoth M, Sabaris G, Couso JP, Nunes MDS, Frankel N, Gómez-Skarmeta JL, Pueyo-Marques J, Arif S, McGregor AP, Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution
PLoS Genetics 14 (5) (2018) ISSN: 1553-7390 eISSN: 1553-7404 Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution Open Access version on RADAR
Schmitt-Engel C, Schultheis D, Schwirz J, Strohlein N, Troelenberg N, Majumdar U, Dao VA, Grossmann D, Richter T, Tech M, Donitz J, Gerischer L, Theis M, Schild I, Trauner J, Koniszewski NDB, Kuster E, Kittelmann S, Hu YG, Lehmann S, Siemanowski J, Ulrich J, Panfilio KA, Schroder R, Morgenstern B, Stanke M, Buchhholz F, Frasch M, Roth S, Wimmer EA, Schoppmeier M, Klingler M, Bucher G, The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology
Nature Communications 6 (2015) ISSN: 2041-1723 eISSN: 2041-1723 The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology Open Access version on RADAR
Arif S, Kittelmann S, McGregor AP, From shavenbaby to the naked valley: trichome formation as a model for evolutionary developmental biology
Evolution & Development 17 (2015) pp.120-126 ISSN: 1520-541X eISSN: 1525-142X
Kittelmann S, Ulrich J, Posnien N, Bucher G, Changes in anterior head patterning underlie the evolution of long germ embryogenesis
Developmental Biology 374 (1) (2013) pp.174-184 ISSN: 0012-1606
Posnien N, Schinko JB, Kittelmann S, Bucher G, Genetics, development and composition of the insect head--a beetle's view
Arthropod Structure & Development 39 (6) (2010) pp.399-410 ISSN: 1467-8039
Schetelig MF, Scolari F, Handler AM, Kittelmann S, Gasperi G, Wimmer EA, Site-specific recombination for the modification of transgenic strains of the Mediterranean fruit fly Ceratitis capitata
Proceedings of the National Academy of Sciences 106 (43) (2009) pp.18171-18176 ISSN: 0027-8424 eISSN: 1091-6490
Schinko J, Posnien N, Kittelmann S, Koniszewski N, Bucher G, Single and Double Whole-Mount In Situ Hybridization in Red Flour Beetle (Tribolium) Embryos
Cold Spring Harbor Protocols 2009 (8) (2009) ISSN: 1940-3402 eISSN: 1559-6095