Membrane Transport Research

About us

Research in our group is aimed at answering both fundamental and applied questions about membrane transport proteins, which move compounds across cell membranes.

In particular, we are interested in using membrane transporters to allow the oral (tablet) uptake of drugs that would normally have to be injected.

We work closely in parallel with input from medicinal chemistry colleagues to design, synthesise and test novel prodrugs in our in vitro systems. 

Crystal structure of the E. coli peptide transporter DtpA in complex with nanobody N00 and the prodrug valganciclovir (highlighted)

Research impact

Unlike free drugs, prodrugs can cross cell membranes on the membrane transporter. Free drug are subsequently released from prodrugs by metabolism.

A major focus of the Membrane Transport Research Group’s work is to design and test novel prodrugs that are targeted to membrane transporters to allow oral absorption of drugs which otherwise would have to be injected. We are therefore aiming to provide better drugs for patients through interactions with industry and commercialisation.

Leadership

David Meredith

Dr David Meredith

Senior Lecturer in Biochemistry / Biomedical Science

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Images Credit

  • "About us" image: "The E. coli peptide transporter DtpA in complex with nanobody N00 and the prodrug valganciclovir" by Yonca Ural-Blimke/Christian Loew (EMBL)

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