- "About us" image: "The E. coli peptide transporter DtpA in complex with nanobody N00 and the prodrug valganciclovir" by Yonca Ural-Blimke/Christian Loew (EMBL)
Research in our group is aimed at answering both fundamental and applied questions about membrane transport proteins, which move compounds across cell membranes.
In particular, we are interested in using membrane transporters to allow the oral (tablet) uptake of drugs that would normally have to be injected.
We work closely in parallel with input from medicinal chemistry colleagues to design, synthesise and test novel prodrugs in our in vitro systems.
A major focus of the Membrane Transport Research Group’s work is to design and test novel prodrugs that are targeted to membrane transporters to allow oral absorption of drugs which otherwise would have to be injected. We are therefore aiming to provide better drugs for patients through interactions with industry and commercialisation.