Biological Sciences (MBiol)

A study of structure and function of prokaryotic and eukaryotic genomes at the molecular level with an overview on the experimental evidence that has contributed to current concepts, models and paradigms and practical experience of key molecular biology laboratory techniques. The module focuses on aspects of genetic engineering and environmental applications of modern molecular tools, with emphasis on phylogeny, ecology and evolution.

This module focuses on eukaryotic cell structures and functions and highlights examples from animals, plants and fungi. The composition and functions of the cytoskeleton, cell membranes and cell components including chloroplasts, mitochondria and the nucleus will be discussed. In addition, cellular processes such as cell division and cell death will also be examined. Students will use well established methods such as fluorescent microscopy of living cells to experimentally investigate topics from lectures in lab classes.

The module aims to provide essential training in professional career management skills designed to assist you in actively planning and preparing for your future career. It will take you through a career development cycle starting with discovering your potential, exploring opportunities (jobs, post graduate study or training), plotting a way forward and making it happen.

Biological applications, whether in industry, academia or health care, are increasingly reliant on generating and analysing high-throughput global level (“-omic”) data. Analysing such high-throughput data requires a new breed of biologists with some level of competency in bioinformatics and computational biology. This module provides an introduction to computational thinking in the biological sciences. This involves learning programming to tailor bespoke solutions to biological problems and developing a capacity to approach biological problems from a computational perspective (computational thinking). Additionally students are introduced to a variety of –omic data types (RNA, DNA, Protein-level), public databases and publicly available software for bioinformatics applications. Bioinformatics provides key highly transferable skills that can be used in academia, or in other work case scenarios.

This module introduces students on how to get biologically meaningful answers from data while providing a generic introduction to concepts of ‘big data’ and machine learning. This conceptual framework is delivered via a more practical approach where students learn how to program, analyse, manage and communicate data from diverse biological disciplines using the R language for statistical computing.

The module emphasises the importance of observation and experimentation to our understanding of behaviour and develops deep reading skills through the study of key primary research papers. Consideration is given to the influences of resource type and quality on animal behaviour, the evolution of behavioural traits and the acquisition of new behaviours.

This module will present students with an in-depth introduction to the principles of developmental biology, and provide a broad overview of development processes and their regulation in animals.

An introduction to microbiology considering the structures, metabolism, regulatory signals, replication and growth exhibited by microorganisms. You will be introduced to a number of examples of microbes, including viruses, bacteria and protozoa, particularly those that are pathogenic in humans. The interaction and impact of microbes with humans will be considered, along with an introduction to the challenges facing medical interventions against pathogenic microbes in different parts of the world. You will learn how to work in a Category 2 microbiology laboratory and have the opportunity to plan and execute simple experimental procedures that are important to work with bacteria and viruses. You will practise aseptic techniques, and several procedures used in diagnostic labs for bacterial identification.

Without plants, life on Earth would look very different to what it is now. Plants provide us with energy and food, shelter, and the oxygen that we breathe. They form the biggest biomass on earth, outnumbering all other organisms by far. We cannot afford to ignore plants when it comes to tackling global issues like climate change, sustainability, preserving biodiversity, finding new medicines, understanding societal inequalities, and living a healthy life.

This module focuses on patterns of genetic inheritance at different scales from individuals to populations to evolutionary lineages. It will develop an understanding of Mendelian/transmission, quantitative, population, ecological and evolutionary genetics and an ability to analyse and interpret genetic data.

The module considers the biochemistry of eukaryotic cells with an emphasis on mammalian tissues. Using several approaches, we will explore the biochemistry of eukaryotic cells, including the chemical nature of the compounds that are involved in cellular processes. Examples of diseases caused by failures in these processes reinforce understanding and provide relevance and application.  The module emphasises relationships between events at the cellular level and at the systemic level, building a clear picture of the importance of biochemical events in human health and disease. In addition, some of the most relevant biomedical diagnostic techniques will be discussed.

An individual project related to some aspect of the student's degree subject. The associated practical work may be conducted in a research or industrial laboratory or in the field, depending on the nature of the project.

This module focuses on the development of the professional skills, personalised to your career ambitions. You will select three ‘podules’ from a selection of podules, which draw upon our research expertise and links with external partners. Podules will cover a wide range topics relevant to your degree, such as advanced microscopy, protein biochemistry, species identification, geographic information systems, entrepreneurship or science communication. Each podule consists of an introductory lecture, plenty of hands-on experience, and a seminar in which you will learn more about the application of ‘your’ skill in different contexts.

A study (normally library-based) of a topic of the student's choosing that is relevant to the student's programme but not formally offered as part of the taught course.  A learning contract is agreed between the student and a supervising member of staff in the semester prior to the one in which the study is to be undertaken, and this must be approved by the Subject Examination Committee. Only once the learning contract has been formally approved will the module be registered on the student's programme of study.

The module will specifically focus on the use of natural variation for the study of population history, selection inference, and analysing variation in complex traits; the use of comparative genomics and phylogenetics to understand evolutionary relationships and investigate gene and genome evolution; the role of microbiomes in human health and ecosystems and the study of gene function. Key techniques discussed include access and retrieval of data from public resources, population statistics, phylogenetics (including co-evolution between genomes), genome-wide association studies, gene annotation, transcriptome analysis, transcription factor binding prediction and characterisation of epigenetic modifications. Students will apply knowledge to devise a research programme addressing one such current challenge in biological and medical science.

This module is designed to give students an in-depth appreciation of currently topical areas in the cell biology of mammals, yeast and plants, and the techniques underpinning the associated research. Topics to be covered will include cell signalling, the endomembrane system, and the cell cycle. Control of these three aspects of cell biology is, ultimately, at the level of interacting proteins and these interactions will be explored. Advanced experimental bio-imaging is one of the most powerful experimental methods for investigation of cell biology and confocal light microscopy will be used in practicals to observe living cells of animals and plants and to measure the strength of protein interactions in different biological situations.

The module will identify and deliver the concepts and practical skills used in wildlife conservation, integrating conservation at the landscape scale with other wider countryside land management. This will develop an understanding of the use of practical conservation management in maintaining and enhancing biodiversity. The inter-disciplinary nature of the module is emphasised in identifying the role of policy and statutory controls for wildlife management, and the role of conservation science in their development and delivery.

The module aims to explore the neurobiological mechanisms underlying behaviour, including memory acquisition, learning and cognition, perception and consciousness at an individual level as well as in a social and ecological context/setting. This module will also cover the major technological advances in the study of neural function and behaviour and the development of diagnostic and therapeutic tools in the treatment of neurological disorders.

The shape, size and colour of each animal are produced during its development. This means that in order to study the evolution of animal biodiversity we need to study the evolution of development. In this module, we will not only discuss animal evolution at various timescales and levels, but we will also follow the development from egg (cell) to adult in a variety of animal species and compare the developmental programmes involved. We will investigate how morphological variation can be generated by tinkering with the expression patterns of a conserved set of toolkit genes, both over evolutionary time and in response to environmental variation, and the central role mothers play in generating morphological variation and modulating the effect of environmental change on development.

An exploration of the nature and causes of cancer with particular emphasis on the molecular biology of underlying mechanisms. The role of oncogenes, tumour suppressor genes, and cell signalling is explored. The role played by other cellular processes such as the cell cycle, apoptosis, cell growth and division, and DNA repair in cancer development is also explored. The module is framed around the concepts of the ‘hallmarks of cancer’ and will also explore the emerging field of cancer genomics as well as cover the therapeutic options for tumour patients.

Science has had a huge impact on all aspects of our lives, and the overall aim of this module is to set that influence in its social and historical context. We will address alternative views of the world, how they have been developed or replaced in the context of science and have a clear look at the strengths and weaknesses of a scientific world view. We will address ideas about the value of other life forms and introduce environmental philosophy.

The ‘Work Experience’ module is a supervised work-based learning experience. You will spend a minimum of 60 hours in a working environment that is relevant to your future career path. By learning how to reflect on your learning and professional development, and how to present your insights in a written essay and in a video, you will develop useful skills for your future job applications.

The module is a period of research practice in a professional working environment. The objective is to augment and develop the skills and competencies delivered by the degree programme, and to practice science in a working context. The period of research practice will allow the student to apply the knowledge and learning gained in their academic training while carrying out their own supervised research in an active research environment. The research will be related to, and draw on, the theoretical knowledge and skills already acquired during the first three years of their degree programme. It is expected that the student will gain scientific and interpersonal skills which complement the learning experience delivered by taught modules. The research practiced carried out as a team member within an active research environment will therefore contribute to the training of talented students interested in careers as practising scientists.