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Department of Biological and Medical Sciences
Faculty of Health and Life Sciences
+44 (0)1865 482778
Administrative Experience and Evidence of Peer-esteem
2016-to date. Advisory Board Member. Innovation Forum, Oxford branch.
2016-to date. iCASE Industrial Panel Committee Member, BBSRC Doctoral training Programme (DTP). Univ. of Oxford-
OBU-Hartwell Research Campus-Pirbright Institute-Diamond Ligh Source, ISIS.
2016-to date. OBU representative, Oxford Academic Health Science Centre (AHSC) Theme 2 Strategy Group.
2014-to date. Knowledge Exchange & Impact Lead for the Department of Biological and Medical Sciences, Oxford
Brookes University (OBU).
2012-2013. Fellow of the Higher Education Academy (HEA) of the United Kingdom.
Taught undergraduate courses. Module U14009: Skills for Life Scientists Module U14505: Chemistry of Cells Module U14525: Biochemistry of Cell Function Module U14591: Molecular Biology of Cancer Module U14675: Evidence Based Medicine and Diagnostics Module U14572: Clinical Biochemistry and Pharmacology Module U15536: The Context of the Cell Module U14584: Advanced Topics in Cell Biology Module U14515: Professional and Experimental Skills Module U14699: Research Project
Taught postgraduate courses: MSc Medical Genetics and Genomics
Module P10101: Molecular Biology
Module P10102: Genome Sciences
Module P10199: Research Project
Miss Natalie L. Curtis. (PhD student) Oxford Brookes University. Start date 01-Sept-2017
Miss Maria Kapanidou. (PhD student) Oxford Brookes University. Start date 01-Sept-2013.
Dr Dave Gervais. PhD by published work. Oxford Brookes University. 2014-2016.
Miss Qian Wu. 2009-2012, PhD. University of Cambridge, England.
Mr. Takashi Ochi. 2008-2012, PhD. University of Cambridge, England.
Miss Deepti Gupta. 2008-2011, PhD. University of Cambridge, England.
Miss Ann Ling. 2008-2011, PhD. University of Cambridge, England.
Mr. Lionel Chieze. 2007-2010, PhD. University of Rennes, France.
Miss Sheena D'Arcy. 2006-2010, PhD. University of Cambridge, England.
Do not hesitate to contact me if you would like to discuss PhD openings and training opportunities.
Member of the Cancer Research UK Oxford Centre.
Member of the Oxford UBIQUITIN Club, University of Oxford
Member of the Biochemical Society.
Member of the Cambridge Cancer Centre (http://www.cancer.cam.ac.uk).
Member of the European Crystallographic Association (ECA).
Member of the British Crystallographic Association (BCA), United Kingdom.
Impact of Published Research
I have developed an original, sustainable and international competitive research programme and generated materials, methods, protocols and data that are used by other researchers around the world. A fraction of my research output has been used as a model case and/or primary citation in manuals and catalogues of well-established commercial suppliers of reagents and biological materials such as GE Healthcare, Hampton Research, Bruker AXS, and New England Biolabs.
My research on cell signalling span basic and translational bioscience that underpins the major strategic objectives of the UK research councils (BBSRC, MRC, EPSRC), charities (The Wellcome Trust, CRUK) and the EU (Horizon 2020 Programme): understanding healthy aging, the molecular basis of tumour formation and growth and of birth and development disorders; developing industrial biotechnology and the control of infectious diseases caused by pathogenic metazoan organisms through the targeting of the mitotic checkpoint-kinetochore-microtubules axis.
2016-to date. iCASE Industrial Panel Committee Member, BBSRC Doctoral training Programme (DTP). Univ. of Oxford-Oxford
Brookes University-Hartwell Research Campus-Pirbright Institute-Diamond Ligh Source, ISIS.
2016-to date. Oxford Brookes University representative, Oxford Academic Health Science Centre (AHSC) Theme 2 Strategy
2015-to date. Member of the Cancer Research UK Oxford Centre.
2015-to date. Member of the Oxford UBIQUITIN Club, University of Oxford
2013-to date. Fellow of the Higher Education Academy (HEA) of the United Kingdom.
2013 - 2014. Editor of Advances in Enzyme Research.
2012-to date. Member of the Biochemical Society.
2009-to date. Member of the Cambridge Cancer Centre (http://www.cancer.cam.ac.uk).
2003-to date. Member of the European Crystallographic Association (ECA).
2000-to date. Member of the British Crystallographic Association (BCA), United Kingdom.
2011-2012. Appointed as a Post-doctoral Teaching Associate after a competitive application process. Department of Biochemistry, University of Cambridge, England. 2006-2012. Research Associate, University of Cambridge. (Department of Biochemistry, Group of Prof. Sir Tom L. Blundell). Cambridge, England.
2005-2011. Small group teaching. Supervisor of the papers MVST Par1A (Molecules in Medical Science) and the Natural Sciences Tripos (Part IA and B and Part II Biochemistry, Molecular and Cellular Biology and Physiology of Organisms) to undergraduate students from Queen’s, St Edmund’s and Homerton College, University of Cambridge, England.
2003-2006. Research Associate, University of Cambridge. (Department of Biochemistry, Group of Prof. Sir Tom L. Blundell in collaboration with Prof. Ashok Venkitaraman, Cambridge). 2000-2003. Wellcome Trust International Research Fellow, Laboratory of Molecular Biology (LMB) of the Medical Research Council (MRC) and the University of Cambridge. Cambridge, United Kingdom.
Cell division is a critical biological event regulated by the spindle assembly checkpoint (SAC), an intricate signalling mechanism of higher organisms that ensures the arrest of cells in mitosis until defects in chromosome attachment are repaired. Mistakes in the SAC can lead to the loss, gain or rearrangements of the genetic material, which is the main cause of spontaneous miscarriage; the origin of birth and developmental defects; genome instability; cancer; and of diverse age-associated pathologies including sarcopenia, cardiac arrhythmias, arterial wall stiffening, impaired wound healing and dermal thinning. In essence, I am trying to understand: a) how the SAC, the kinetochore and microtubules work together to ensure the accurate separation of chromosomes when cells divide; b) details of how the import into the nucleus of certain SAC proteins by nuclear transport receptors regulates the process; c) explore ways in which the structural and mechanistic understanding of the interactions can be translated into the clinic.
My years of experience in teaching in Higher Education institutions in the UK spans different areas and settings and include lecturing, supervision and teaching to small groups, preparation of teaching material and examination papers, marking of coursework and exams, development of new postgraduate teaching programmes, mentoring, examination of PhD and MSc dissertations and the day-to-day supervision of undergraduate and postgraduate students and overseas research visitors. The majority of my former students from Cambridge, Oxford, and overseas have stayed in touch long after the termination of their courses/research projects. They often said they have found the experience of working under my supervision as inspiring, challenging and intellectually stimulating. They usually contact me for advice as they progress in their careers and/or ask me to write letters of reference to support scholarship and/or admission applications to postgraduate programmes at Biomedical Schools in the UK and abroad.
Please do not hesitate to contact me at any time if you are interested in our research and would like to discuss Postdoctoral openings, PhD and training opportunities.